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PMID: 16343 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Direct resorption of bone by human monocytes.

Science (New York, N.Y.) ·Vol. 196 ·No. 4294 ·1977-06-03 ·Pages 1109-11

Mundy CR, Altman AJ, Gondek MD, Bandelin JG

Abstract

Cultured human peripheral blood monocytes stimulate the release of bone mineral and matrix from killed long bones of fetal rats. These effects were inhibited by cortisol but were not altered by hormones that normally stimulate osteoclastic bone resorption. There was no evidence of morphologic differentiation of the monocytes into osteoclasts during bone resorption.

MeSH Terms

Animals Bone Resorption/drug effects Bone and Bones/physiology Calcitonin/pharmacology Cell Adhesion Dihydroxycholecalciferols/pharmacology Humans Hydrocortisone/pharmacology Hydrogen-Ion Concentration In Vitro Techniques Macrophages/physiology Monocytes/physiology Parathyroid Hormone/pharmacology Rats

Chemicals

Dihydroxycholecalciferols Parathyroid Hormone Calcitonin Hydrocortisone

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Mundy C R

Altman A J

Gondek M D

Bandelin J G

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.16343

Published

1977-06-03

Pages

1109-11

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.16343 View journal details

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Direct resorption of bone by human monocytes.

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