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PMID: 16355212 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Lymphangiogenesis in development and human disease.

Nature ·Vol. 438 ·No. 7070 ·2005-12-15 ·Pages 946-53

Alitalo K, Tammela T, Petrova TV

Abstract

The lymphatic vasculature forms a vessel network that drains interstitial fluid from tissues and returns it to the blood. Lymphatic vessels are also an essential part of the body's immune defence. They have an important role in the pathogenesis of several diseases, such as cancer, lymphoedema and various inflammatory conditions. Recent biological and technological developments in lymphatic vascular biology will lead to a better understanding and treatment of these diseases.

MeSH Terms
Animals Disease Endothelial Cells/drug effects,metabolism Humans Inflammation/physiopathology Lymphangiogenesis/drug effects,physiology Lymphatic Metastasis Lymphatic Vessels/cytology,drug effects,pathology,physiology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Alitalo Kari
Molecular/Cancer Biology Laboratory, Ludwig Institute for Cancer, Research, P.O.B. 63 (Haartmaninkatu 8), 00014 University of Helsinki, Finland. [email protected]
Tammela Tuomas
Petrova Tatiana V
Article Info
Journal
Nature
Abbr.
Nature
ISSN
1476-4687
Published
2005-12-15
Pages
946-53
Language
English
Region
England
NLM ID
0410462
Subset
IM
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