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PMID: 16356449 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Male/female differences in indomethacin effects in preterm infants.

The Journal of pediatrics ·Vol. 147 ·No. 6 ·2005-12-00 ·Pages 860-2

Ohlsson A, Roberts RS, Schmidt B, Davis P, Moddeman D, Saigal S, Solimano A, Vincer M, Wright L, Trial Of Indomethacin Prophylaxis In Preterms Tipp Investigators

Abstract

To test whether indomethacin prophylaxis has sex-mediated effects on severe intraventricular hemorrhage (grade III and IV) and on long-term outcomes in extremely-low-birth-weight infants. A secondary analysis was performed in the entire "Trial of Indomethacin Prophylaxis in Preterms study" cohort. The results suggest a weak differential treatment effect of indomethacin by sex.

MeSH Terms
Anti-Inflammatory Agents, Non-Steroidal/therapeutic use Cerebral Ventricles Developmental Disabilities/prevention & control Female Humans Indomethacin/therapeutic use Infant, Newborn Infant, Premature Infant, Very Low Birth Weight Intracranial Hemorrhages/prevention & control Male Sex Factors Treatment Outcome
Chemicals
Anti-Inflammatory Agents, Non-Steroidal Indomethacin
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Ohlsson Arne
University of Toronto, Toronto, McMaster University, Hamilton, Ontario, Canada.
Roberts Robin S
Schmidt Barbara
Davis Peter
Moddeman Diane
Saigal Saroj
Solimano Alfonso
Vincer Michael
Wright Linda
Trial Of Indomethacin Prophylaxis In Preterms Tipp Investigators
Article Info
Journal
The Journal of pediatrics
Abbr.
J Pediatr
ISSN
0022-3476
DOI
10.1016/j.jpeds.2005.07.032
Published
2005-12-00
Pages
860-2
Language
English
Region
United States
NLM ID
0375410
Subset
IM
Grants
NCRR NIH HHS · M01 RR 00070 · United States
NCRR NIH HHS · M01 RR 00997 · United States
NICHD NIH HHS · U10 HD21364 · United States
NICHD NIH HHS · U10 HD21373 · United States
NICHD NIH HHS · U10 HD21385 · United States
NICHD NIH HHS · U10 HD27851 · United States
NICHD NIH HHS · U10 HD27880 · United States
NICHD NIH HHS · U10 HD27881 · United States
NICHD NIH HHS · U10 HD27904 · United States
NICHD NIH HHS · U10 HD34216 · United States
External Links
PubMed source DOI: 10.1016/j.jpeds.2005.07.032 View journal details
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