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PMID: 16362039 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

CLIP-170 facilitates the formation of kinetochore-microtubule attachments.

The EMBO journal ·Vol. 25 ·No. 1 ·2006-01-11 ·Pages 45-57

Tanenbaum ME, Galjart N, van Vugt MA, Medema RH

Abstract

CLIP-170 is a microtubule 'plus end tracking' protein involved in several microtubule-dependent processes in interphase. At the onset of mitosis, CLIP-170 localizes to kinetochores, but at metaphase, it is no longer detectable at kinetochores. Although RNA interference (RNAi) experiments have suggested an essential role for CLIP-170 during mitosis, the molecular function of CLIP-170 in mitosis has not yet been revealed. Here, we used a combination of high-resolution microscopy and RNAi-mediated depletion to study the function of CLIP-170 in mitosis. We found that CLIP-170 dynamically localizes to the outer most part of unattached kinetochores and to the ends of growing microtubules. In addition, we provide evidence that a pool of CLIP-170 is transported along kinetochore-microtubules by the dynein/dynactin complex. Interference with CLIP-170 expression results in defective chromosome congression and diminished kinetochore-microtubule attachments, but does not detectibly affect microtubule dynamics or kinetochore-microtubule stability. Taken together, our results indicate that CLIP-170 facilitates the formation of kinetochore-microtubule attachments, possibly through direct capture of microtubules at the kinetochore.

MeSH Terms
Cells, Cultured Chromosomes/metabolism Dynactin Complex Dyneins/metabolism Humans Kinetochores/chemistry,metabolism Microtubule-Associated Proteins/analysis,genetics,metabolism Microtubules/chemistry,metabolism Mitosis Neoplasm Proteins/analysis,genetics,metabolism RNA Interference Spindle Apparatus/chemistry,metabolism
Chemicals
Dynactin Complex Microtubule-Associated Proteins Neoplasm Proteins cytoplasmic linker protein 170 Dyneins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Tanenbaum Marvin E
Division of Molecular Biology, Netherlands Cancer Institute, Amsterdam, The Netherlands
Galjart Niels
van Vugt Marcel A T M
Medema René H
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
Published
2006-01-11
Epub
2005-00-15
Pages
45-57
Language
English
Region
England
NLM ID
8208664
PMCID
PMC1356359
Subset
IM
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