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PMID: 16371946 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Oligodendrocyte wars.

Nature reviews. Neuroscience ·Vol. 7 ·No. 1 ·2006-01-00 ·Pages 11-8

Richardson WD, Kessaris N, Pringle N

Abstract

Oligodendrocyte precursors first arise in a restricted ventral part of the embryonic spinal cord and migrate laterally and dorsally from there. Later, secondary sources develop in the dorsal cord. Normally, the ventrally-derived precursors compete with and suppress their dorsal counterparts. There are also ventral and dorsal sources in the forebrain, but here the more dorsal precursors prevail and the ventral-most lineage is eliminated during postnatal life. How do the different populations compete and what is the outcome of the competition? Do different embryonic origins signify different functional subgroups of oligodendrocyte?

MeSH Terms
Animals Cell Differentiation Central Nervous System/cytology,embryology,growth & development Embryonic Development/physiology Oligodendroglia/physiology Stem Cells/physiology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Richardson William D
Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK. [email protected]
Kessaris Nicoletta
Pringle Nigel
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Article Info
Journal
Nature reviews. Neuroscience
Abbr.
Nat Rev Neurosci
ISSN
1471-003X
DOI
10.1038/nrn1826
Email
[email protected]
Published
2006-01-00
Pages
11-8
Language
English
Region
England
NLM ID
100962781
PMCID
PMC6328010
Subset
IM
Grants
Wellcome Trust · 066745 · United Kingdom
Medical Research Council · G0800575 · United Kingdom
Medical Research Council · G0501173 · United Kingdom
Medical Research Council · G9708005 · United Kingdom
Wellcome Trust · United Kingdom
External Links
PubMed source DOI: 10.1038/nrn1826 PMC Full Text View journal details
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