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PMID: 16373058 Published · ppublish English Journal Article Review

Double minutes, cytogenetic equivalents of gene amplification, in human neoplasia - a review.

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico ·Vol. 7 ·No. 11 ·2005-12-00 ·Pages 477-85

Gebhart E

Abstract

Double minutes are tiny spherical chromatin bodies of a few mega-base pairs of size which are found occasionally in hematopoietic neoplasia and more or less often in human solid tumors. They have been associated with worse prognosis and poor outcome of the malignancies where present. With the beginning era of molecular cytogenetics they could be defined as cytogenetic equivalents of amplified DNA sequences. The identification of involved chromosomal segments and their molecular nature led to the development of molecular genetic techniques for a rapid and reliable detection of prognostically important oncogene amplifications in human tumors and,as a consequence, to gene-targeted therapy.

MeSH Terms
Chromatin/ultrastructure DNA, Neoplasm/genetics Drug Resistance, Neoplasm/genetics Gene Amplification Hematologic Neoplasms/genetics,pathology Humans Neoplasm Proteins/genetics Neoplasms/genetics,pathology,therapy Oncogenes Polymerase Chain Reaction Prognosis Tetrahydrofolate Dehydrogenase/genetics
Chemicals
Chromatin DNA, Neoplasm Neoplasm Proteins Tetrahydrofolate Dehydrogenase
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Gebhart Erich
Institute of Human Genetics, University of Erlangen-Nürnberg, Germany. [email protected]
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Article Info
Journal
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Abbr.
Clin Transl Oncol
ISSN
1699-048X
DOI
10.1007/BF02717000
Email
[email protected]
Published
2005-12-00
Pages
477-85
Language
English
Region
Italy
NLM ID
101247119
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02717000 View journal details
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