Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue.

Biochimica et biophysica acta ·Vol. 1732 ·No. 1-3 ·2005-12-30 ·Pages 96-102

Schäffler A, Neumeier M, Herfarth H, Fürst A, Schölmerich J, Büchler C

Abstract

Genomic structure, promoter region, amino acid sequence and exon-specific primer combinations of the human omentin gene are presented. Omentin mRNA expression differs between omental adipose tissue probes from patients with chronic inflammatory bowel diseases such as Crohn's disease. Sequence comparisons revealed a 100% identity of omentin with human intelectin. Based on this, omentin might be a new adipocytokine playing a role in the defense against intestinal bacterial translocation in the context of Crohn's disease.

MeSH Terms

Adipose Tissue/metabolism Adult Amino Acid Sequence Base Sequence Binding Sites/genetics Cytokines/chemistry,genetics Exons/genetics Female GPI-Linked Proteins Genome, Human/genetics Genomics Humans Hydrophobic and Hydrophilic Interactions Lectins/chemistry,genetics Male Middle Aged Molecular Sequence Data Omentum/metabolism Promoter Regions, Genetic/genetics RNA, Messenger/genetics,metabolism

Chemicals

Cytokines GPI-Linked Proteins ITLN1 protein, human Lectins RNA, Messenger

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Schäffler A

Department of Internal Medicine I, University of Regensburg, D-93042 Regensburg, Germany. [email protected]

Neumeier M

Herfarth H

Fürst A

Schölmerich J

Büchler C

Article Info

Journal

Biochimica et biophysica acta

Abbr.

Biochim Biophys Acta

ISSN

0006-3002

DOI

10.1016/j.bbaexp.2005.11.005

[email protected]

Published

2005-12-30

Epub

2005-00-19

Pages

96-102

Language

English

Region

Netherlands

NLM ID

0217513

Subset

Databases

GENBANK

AY549722

External Links

PubMed source DOI: 10.1016/j.bbaexp.2005.11.005

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Genomic structure of human omentin, a new adipocytokine expressed in omental adipose tissue.

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