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PMID: 1640832 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Ferrioxamine uptake in Yersinia enterocolitica: characterization of the receptor protein FoxA.

Molecular microbiology ·Vol. 6 ·No. 10 ·1992-05-00 ·Pages 1309-21

Bäumler AJ, Hantke K

Abstract

The gene for the high-affinity outer membrane ferrioxamine receptor FoxA of Yersinia enterocolitica was cloned in Escherichia coli K-12. A foxA mutant of Yersinia could be complemented by the cloned DNA fragment. The FoxA encoding region was sequenced and an open reading frame encoding 710 amino acids, including a signal sequence of 26 amino acids, was deduced. The mature FoxA protein consisted of 684 amino acids and had a molecular mass of 75,768 Da. FoxA shared 33% amino acid sequence homology with FhuA, the ferrichrome receptor of Escherichia coli. Based on the homologies with FhuA and other TonB-dependent receptors a topological model of FoxA is presented.

Related Genes

btuB cir colB colD colIa colM entC fecA fepA fepD fhuA fhuE foxA iutA pupA rfeA tonB

MeSH Terms

Amino Acid Sequence Bacterial Outer Membrane Proteins/genetics,metabolism Bacterial Proteins/metabolism Base Sequence Consensus Sequence Deferoxamine/metabolism Escherichia coli/genetics Escherichia coli Proteins Ferric Compounds/metabolism Genes, Bacterial Membrane Proteins/metabolism Models, Molecular Molecular Sequence Data Multigene Family Protein Conformation Protein Sorting Signals/genetics Receptors, Cell Surface Receptors, Drug/genetics,metabolism Receptors, Virus/genetics Recombinant Proteins/metabolism Rhodobacter capsulatus/genetics Sequence Homology, Nucleic Acid Species Specificity Yersinia enterocolitica/genetics,metabolism

Chemicals

Bacterial Outer Membrane Proteins Bacterial Proteins Escherichia coli Proteins Ferric Compounds FhuA protein, E coli FoxA protein, bacteria FoxB protein, E coli Membrane Proteins Protein Sorting Signals Receptors, Cell Surface Receptors, Drug Receptors, Virus Recombinant Proteins tonB protein, Bacteria tonB protein, E coli ferrioxamine B Deferoxamine

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Bäumler A J

Mikrobiologie II, Universität Tübingen, Germany.

Hantke K

Article Info

Journal

Molecular microbiology

Abbr.

Mol Microbiol

ISSN

0950-382X

DOI

10.1111/j.1365-2958.1992.tb00852.x

Published

1992-05-00

Pages

1309-21

Language

English

Region

England

NLM ID

8712028

Subset

Databases

GENBANK

X60447

External Links

PubMed source DOI: 10.1111/j.1365-2958.1992.tb00852.x View journal details

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Ferrioxamine uptake in Yersinia enterocolitica: characterization of the receptor protein FoxA.

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