Home LiteratureArticle Details
PMID: 1640933 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Relevance of glutamine metabolism to tumor cell growth.

Molecular and cellular biochemistry ·Vol. 113 ·No. 1 ·1992-07-06 ·Pages 1-15

Medina MA, Sánchez-Jiménez F, Márquez J, Rodríguez Quesada A, Núñez de Castro I

Abstract

暂无摘要

MeSH Terms
Animals Biological Transport, Active Glutamine/analogs & derivatives,metabolism,therapeutic use Humans Mitochondria/metabolism Neoplasms/drug therapy,metabolism
Chemicals
Glutamine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Medina M A
Laboratorio de Bioquímica y Biología Molecular, Facultad de Ciencias, Universidad de Málaga, Spain.
Sánchez-Jiménez F
Márquez J
Rodríguez Quesada A
Núñez de Castro I
References (137)
137 references, click to expand
  1. Competition for host essential and nonessential fatty acids by Ehrlich ascites carcinoma in mice.
    Cancer Res. 1977 Jul;37(7 Pt 1):2218-25 PMID: 861947
  2. Growth of pancreatic foci and development of pancreatic cancer with a single dose of azaserine in the rat.
    Carcinogenesis. 1987 Dec;8(12):1831-5 PMID: 3499996
  3. Renal metabolism of amino acids and ammonia in subjects with normal renal function and in patients with chronic renal insufficiency.
    J Clin Invest. 1980 May;65(5):1162-73 PMID: 7364943
  4. Protein metabolism in the tumour-bearing mouse. Rates of protein synthesis in host tissues and in an Ehrlich ascites tumour at different stages in tumour growth.
    Biochem J. 1989 Dec 15;264(3):713-9 PMID: 2619712
  5. Glutamine metabolism in skeletal muscles from the broiler chick (Gallus domesticus) and the laboratory rat (Rattus norvegicus)
    Biochem J. 1991 Mar 15;274 ( Pt 3):769-74 PMID: 2012604
  6. Glutamine-enriched diets support muscle glutamine metabolism without stimulating tumor growth.
    J Surg Res. 1990 Apr;48(4):319-23 PMID: 2338817
  7. Overview of mitochondrial metabolite transport systems.
    Methods Enzymol. 1979;56:245-52 PMID: 459868
  8. Localization and some properties of phosphate-dependent glutaminase in disrupted liver mitochondria.
    Biochem J. 1980 Nov 15;192(2):537-42 PMID: 7236224
  9. Importance of the flux of phosphate across the inner membrane of kidney mitochondria for the activation of glutaminase and the transport of glutamine.
    Biochim Biophys Acta. 1976 Jun 8;430(3):399-412 PMID: 938640
  10. Hepatic glutamine metabolism under the influence of the portal ammonia concentration in the perfused rat liver.
    Eur J Biochem. 1979 Nov 1;101(1):179-84 PMID: 510303
  11. Metabolic alterations in cancer. Part II. Protein and fat metabolism.
    S Afr Med J. 1981 Apr 11;59(16):553-6 PMID: 7013107
  12. [Inactivation of microbial glutamin-(asparagin-)ase by azaserine and 6-diazo-5-oxo-L-norleucine].
    Biull Eksp Biol Med. 1985 Dec;100(12):696-8 PMID: 4074870
  13. Evidence for an essential sulfhydryl group at the substrate binding site of the A-system transporter of Ehrlich cell plasma membranes.
    Biochem Cell Biol. 1990 Feb;68(2):512-9 PMID: 2160834
  14. Electrogenic amino acid transport.
    Can J Physiol Pharmacol. 1979 Jan;57(1):1-15 PMID: 371765
  15. Species differences in renal glutamine synthesis in vivo.
    Am J Physiol. 1969 Jan;216(1):117-22 PMID: 5765570
  16. The inhibitory effects of sulphydryl reagents on the transport and hydrolysis of glutamine in rat-liver mitochondria.
    Eur J Biochem. 1981 Oct;119(3):523-9 PMID: 7308198
  17. A quantitative approach to metabolic control.
    Curr Top Cell Regul. 1985;25:21-76 PMID: 3893903
  18. Uptake of glutamine antimetabolites 6-diazo-5-oxo-L-norleucine (DON) and acivicin in sensitive and resistant tumor cell lines.
    Int J Cancer. 1988 May 15;41(5):752-5 PMID: 3366493
  19. Patterns of amino acid biosynthesis from labeled glucose.
    Cancer Res. 1956 Feb;16(2):117-22 PMID: 13293650
  20. Evidence that glutamine, not sugar, is the major energy source for cultured HeLa cells.
    J Biol Chem. 1979 Apr 25;254(8):2669-76 PMID: 429309
  21. Uptake and metabolism of plasma glutamine by the small intestine.
    J Biol Chem. 1974 Aug 25;249(16):5070-9 PMID: 4605420
  22. Glycolysis, glutaminolysis and cell proliferation.
    Cell Biol Int Rep. 1982 Jul;6(7):635-50 PMID: 6751566
  23. Phase II study of acivicin in non-small cell lung cancer: a National Cancer Institute of Canada Study.
    Cancer Treat Rep. 1986 Nov;70(11):1327-8 PMID: 3021326
  24. Phase II trial of acivicin in patients with advanced epithelial ovarian carcinoma. A Gynecologic Oncology Group Study.
    Invest New Drugs. 1986;4(1):49-52 PMID: 3700040
  25. Hepatic glutaminase flux regulation of glutamine homeostasis. Studies in vivo.
    Biol Chem Hoppe Seyler. 1986 Apr;367(4):301-5 PMID: 3718673
  26. The effect of an Ehrlich ascites tumour on the rate of protein synthesis in muscle and liver of the host [proceedings].
    Biochem Soc Trans. 1980 Jun;8(3):354 PMID: 7399089
  27. Glutamine transport and metabolism by mitochondria from dog renal cortex. General properties and response to acidosis and alkalosis.
    J Biol Chem. 1975 Oct 25;250(20):8148-58 PMID: 1181338
  28. L-glutamine: a major substrate for tumor cells in vivo?
    J Cancer Res Clin Oncol. 1987;113(3):209-15 PMID: 3584211
  29. The effect of metabolic acidosis on the synthesis and turnover of rat renal phosphate-dependent glutaminase.
    Biochem J. 1986 Jan 1;233(1):139-44 PMID: 3954723
  30. Metabolic alterations in cancer. Part I. Carbohydrate metabolism.
    S Afr Med J. 1981 Apr 4;59(15):518-21 PMID: 7013105
  31. Metabolism and action of amino acid analog anti-cancer agents.
    Pharmacol Ther. 1990;46(2):243-71 PMID: 2108451
  32. Tumor-caused changes in host protein synthesis under different dietary situations.
    Cancer Res. 1976 Nov;36(11 Pt 1):3936-40 PMID: 1086130
  33. Effects of acivicin and dichloroallyl lawsone upon pyrimidine biosynthesis in mouse L1210 leukemia cells.
    J Biol Chem. 1986 Nov 15;261(32):14891-5 PMID: 3771555
  34. Factors regulating amino acid release from extrasplanchnic tissues in the rat. Interactions of alanine and glutamine.
    Biochem J. 1975 Sep;150(3):379-87 PMID: 2155
  35. Arteriovenous differences for amino acids and lactate across kidneys of normal and acidotic rats.
    Biochem J. 1976 Oct 15;160(1):125-8 PMID: 1008842
  36. Glutamine synthetase and glutamyltransferase in the kidney of man, dog, and rat.
    Am J Physiol. 1976 Oct;231(4):1068-73 PMID: 10736
  37. Glutamine transport by mitochondria isolated from normal and acidotic rats.
    Am J Physiol. 1975 Oct;229(4):1027-33 PMID: 1190314
  38. Measurements of the turnover rate of glutamine in normal and acidotic rats.
    Biochem J. 1983 Jan 15;210(1):277-80 PMID: 6847647
  39. Malate-citrate cycle during glycolysis and glutaminolysis in Ehrlich ascites tumor cells.
    Biochimie. 1987 May;69(5):469-74 PMID: 3118962
  40. Amino acid utilization and urine protein excretion in children treated with succinylated Acinetobacter glutaminase-asparaginase.
    Cancer Res. 1981 Jun;41(6):2056-62 PMID: 7016307
  41. Nutrition and cancer: physiological interrelationships.
    Annu Rev Nutr. 1985;5:435-61 PMID: 3927950
  42. Reduction of tumor growth following treatment with a glutamine antimetabolite.
    Life Sci. 1988;42(1):87-94 PMID: 3336272
  43. Amino acids and glucose utilization by different metabolic pathways in ascites-tumour cells.
    Eur J Biochem. 1981 Jun;117(1):19-25 PMID: 6790281
  44. Control of enzymic programs and nucleotide pattern in cancer cells by acivicin and tiazofurin.
    Adv Enzyme Regul. 1984;22:69-93 PMID: 6206692
  45. Mouse liver free amino acids during the development of Ehrlich ascites tumour.
    Cancer Lett. 1991 Jul 4;58(3):221-4 PMID: 1855197
  46. Metabolic patterns for glucose-1-C14 in tissues of tumor-bearing rats.
    Cancer Res. 1960 Jan;20:50-7 PMID: 13806376
  47. Effect of acivicin on glutamine transport by rat renal brush border membrane vesicles.
    J Lab Clin Med. 1986 Oct;108(4):301-8 PMID: 2876045
  48. Glutamine synthetase and glutaminase activities in various hepatoma cells.
    Biochem Int. 1989 Aug;19(2):219-25 PMID: 2573354
  49. Direct methods for measuring metabolite transport and distribution in mitochondria.
    Methods Enzymol. 1979;56:279-301 PMID: 459869
  50. Nitrogen utilization in mice bearing Ehrlich ascites tumor treated with Acinetobacter glutaminase-asparaginase.
    Cancer Res. 1981 Jun;41(6):2051-5 PMID: 7237413
  51. Interaction of azaserine and raw soya flour on the rat pancreas.
    Scand J Gastroenterol. 1981;16(1):49-56 PMID: 7195064
  52. Simple and effective purification of a Na+-dependent amino acid transport system from Ehrlich ascites cell plasma membrane.
    Proc Natl Acad Sci U S A. 1988 Nov;85(21):7877-81 PMID: 2847146
  53. Role of amino acid transport and countertransport in nutrition and metabolism.
    Physiol Rev. 1990 Jan;70(1):43-77 PMID: 2404290
  54. A comparative study of glytaminase isozymes in rat tissues.
    Enzyme. 1976;21(5):408-26 PMID: 954714
  55. Regulation of renal ammoniagenesis. Subcellular localization of rat kidney glutaminase isoenzymes.
    J Biol Chem. 1974 May 25;249(10):3261-6 PMID: 4364420
  56. Multi-enzyme-targeted chemotherapy by acivicin and actinomycin.
    Adv Enzyme Regul. 1982;20:75-96 PMID: 6180609
  57. The function of redox shuttles during aerobic glycolysis in two strains of Ehrlich ascites tumor cells.
    Biochimie. 1985 Feb;67(2):259-64 PMID: 4005310
  58. Insulin and acivicin improve host nutrition and prevent tumor growth during total parenteral nutrition.
    Ann Surg. 1988 Oct;208(4):524-31 PMID: 3140745
  59. Respiration of mitochondria isolated from differentiated and undifferentiated HT29 colon cancer cells in the presence of various substrates and ADP generating systems.
    Int J Biochem. 1990;22(4):411-7 PMID: 2159927
  60. Renal mitochondrial glutamine transport and metabolism: studies with a rapid-mixing, rapid-filtration technique.
    Am J Physiol. 1978 Jun;234(6):F514-21 PMID: 27102
  61. Asparaginase as a drug for treatment of acute lymphoblastic leukaemia.
    Essays Biochem. 1989;24:1-40 PMID: 2676522
  62. Glutamine transport in submitochondrial particles.
    Am J Physiol. 1989 Dec;257(6 Pt 2):F1050-8 PMID: 2690640
  63. Metabolite transport in mitochondria.
    Annu Rev Biochem. 1979;48:871-922 PMID: 38739
  64. Characteristics of an amino acid transport system in rat liver for glutamine, asparagine, histidine, and closely related analogs.
    J Biol Chem. 1980 May 10;255(9):4011-9 PMID: 7372663
  65. Glutamine: a major energy source for cultured mammalian cells.
    Fed Proc. 1984 Jan;43(1):121-5 PMID: 6690331
  66. Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver.
    Eur J Biochem. 1983 Jun 15;133(2):269-75 PMID: 6852039
  67. The effects of tumour necrosis factor-alpha (cachectin) and tumour growth on hepatic amino acid utilization in the rat.
    Biochem J. 1990 Feb 15;266(1):123-6 PMID: 2310368
  68. Bioenergetics of tumor cells: glutamine metabolism in tumor cell mitochondria.
    Int J Biochem. 1987;19(4):303-7 PMID: 2885235
  69. Glutaminolysis and glycolysis interactions in proliferant cells.
    Int J Biochem. 1990;22(7):681-3 PMID: 2205518
  70. The possible role of glutamine substrate cycles in skeletal muscle.
    Biochem J. 1991 Oct 1;279 ( Pt 1):327-8 PMID: 1834055
  71. Altered ornithine metabolism in tumor-bearing mice.
    Life Sci. 1989;45(20):1877-84 PMID: 2601556
  72. The pathways of glutamate and glutamine oxidation by tumor cell mitochondria. Role of mitochondrial NAD(P)+-dependent malic enzyme.
    J Biol Chem. 1984 May 25;259(10):6215-21 PMID: 6144677
  73. Contribution by host tissues to circulating glutamine in mice inoculated with Ehrlich ascites tumor cells.
    Cancer Res. 1988 Mar 15;48(6):1551-3 PMID: 2894241
  74. Purification, kinetic behavior, and regulation of NAD(P)+ malic enzyme of tumor mitochondria.
    J Biol Chem. 1984 May 25;259(10):6222-7 PMID: 6725250
  75. In vitro and in vivo anti-tumor activity of L-glutamic acid gamma-monohydroxamate against L1210 leukemia and B16 melanoma.
    Int J Cancer. 1990 Apr 15;45(4):737-43 PMID: 2323850
  76. Some aspects of nitrogen and energy metabolism in cancerous subjects: a review.
    Cancer Res. 1951 Nov;11(11):821-9 PMID: 14886929
  77. COMPARATIVE BIOCHEMISTRY OF HEPATOMAS. V. STUDIES ON AMINO ACID INCORPORATION IN LIVER TUMORS OF DIFFERENT GROWTH RATES.
    Cancer Res. 1963 Aug;23:1003-7 PMID: 14050750
  78. The rediscovery of DON (6-diazo-5-oxo-L-norleucine).
    Recent Results Cancer Res. 1980;74:258-63 PMID: 7192426
  79. Inactivation by acivicin of carbamoyl-phosphate synthetase II of human colon carcinoma.
    Biochem Pharmacol. 1985 Jan 1;34(1):97-100 PMID: 3966920
  80. Altered amino acid kinetics in rats with progressive tumor growth.
    Cancer Res. 1982 Mar;42(3):824-9 PMID: 7059980
  81. Amino acid extraction and ammonia metabolism by the human kidney during the prolonged administration of ammonium chloride.
    J Clin Invest. 1963 Feb;42:263-76 PMID: 13940831
  82. Enhancement of antitumor activity of glutamine antagonists 6-diazo-5-oxo-L-norleucine and acivicin in cell culture by glutaminase-asparaginase.
    Cancer Res. 1981 Apr;41(4):1324-8 PMID: 7214322
  83. DISTINCT MEDIATING SYSTEMS FOR THE TRANSPORT OF NEUTRAL AMINO ACIDS BY THE EHRLICH CELL.
    J Biol Chem. 1963 Nov;238:3686-99 PMID: 14109206
  84. The energy state of tumor-bearing rats.
    J Biol Chem. 1991 Feb 15;266(5):2978-82 PMID: 1993670
  85. Glutaminase of the human malignant cell, strain HeLa.
    J Biol Chem. 1958 May;232(1):229-36 PMID: 13549413
  86. Prevention of central nervous system toxicity of the antitumor antibiotic acivicin by concomitant infusion of an amino acid mixture.
    Cancer Res. 1990 Sep 1;50(17):5475-80 PMID: 2386952
  87. Amino acid metabolism in man.
    Annu Rev Biochem. 1975;44:933-55 PMID: 1094924
  88. Evidence of an intracellular dissipative structure.
    Z Naturforsch C J Biosci. 1988 Sep-Oct;43(9-10):793-4 PMID: 3245272
  89. Phase II trial of acivicin in patients with advanced colorectal carcinoma.
    Am J Clin Oncol. 1986 Jun;9(3):189-91 PMID: 3728371
  90. Measurement of 'in situ' mitochondrial membrane potential in Ehrlich ascites tumor cells during aerobic glycolysis.
    Biochim Biophys Acta. 1988 Oct 5;935(3):322-32 PMID: 3167052
  91. Response of tumor and host to hyperalimentation and antiglutamine treatments.
    JPEN J Parenter Enteral Nutr. 1990 Mar-Apr;14(2):122-8 PMID: 2112618
  92. Inorganic phosphate and energy charge compartmentation in Ehrlich ascites tumour cells in the presence of glucose and/or glutamine.
    Biochem Int. 1988 Apr;16(4):713-8 PMID: 3390197
  93. Ketone body, glucose, lactic acid, and amino acid utilization by tumors in vivo in fasted rats.
    Cancer Res. 1983 Aug;43(8):3497-503 PMID: 6861121
  94. Acivicin. An antitumor antibiotic.
    Cancer Clin Trials. 1981 Fall;4(3):327-30 PMID: 7026076
  95. L-glutamine transport in native vesicles isolated from Ehrlich ascites tumor cell membranes.
    J Bioenerg Biomembr. 1991 Aug;23(4):689-97 PMID: 1917914
  96. Glucagon and epinephrine effect on blood glucose levels in rats carrying Yoshida solid sarcoma and Walker-256 carcinosarcoma.
    Biomedicine. 1979 Sep;31(5):139-41 PMID: 508897
  97. Methodology for transport studies: graphical and computer curve fitting methods for glutamate and aspartate efflux kinetics.
    Methods Enzymol. 1979;56:252-78 PMID: 37411
  98. Phase II trial of 6-diazo-5-oxo-L-norleucine versus aclacinomycin-A in advanced sarcomas and mesotheliomas.
    Invest New Drugs. 1990 Feb;8(1):113-9 PMID: 2188926
  99. Enzyme targets of antiglutamine agents in cancer chemotherapy.
    Adv Enzyme Regul. 1985;24:207-23 PMID: 2424283
  100. Early systemic effects on the hepatic mitochondria of tumour bearing mice.
    Cancer Lett. 1989 Mar;44(3):179-83 PMID: 2647283
  101. Biochemical pharmacology of acivicin in rat hepatoma cells.
    Biochem Pharmacol. 1982 Nov 1;31(21):3469-73 PMID: 7150366
  102. The transport and metabolism of glutamine by kidney-cortex mitochondria from normal and acidotic rats.
    Biochem J. 1977 May 15;164(2):331-7 PMID: 560188
  103. On the multiform relationships between the tumor and the host.
    Adv Cancer Res. 1979;30:89-150 PMID: 388993
  104. Distribution of hepatic glutaminase activity and mRNA in perivenous and periportal rat hepatocytes.
    Biochem J. 1990 Apr 1;267(1):265-7 PMID: 1970242
  105. Effect of L-glutamine antagonists on 5-phosphoribosyl 1-pyrophosphate levels in P388 leukemia and in murine colon adenocarcinomas in vivo.
    Biochem Pharmacol. 1982 Apr 15;31(8):1509-13 PMID: 6178415
  106. Glycolysis and glutaminolysis in perifused Ehrlich ascites tumour cells.
    Cell Biochem Funct. 1989 Jan;7(1):7-10 PMID: 2752538
  107. Glutamine and glucose metabolism during thymocyte proliferation. Pathways of glutamine and glutamate metabolism.
    Biochem J. 1985 Jun 1;228(2):353-61 PMID: 2861809
  108. Kinetics of cell proliferation and polyamine synthesis during Ehrlich ascites tumor growth.
    Cancer Res. 1977 Dec;37(12):4361-6 PMID: 922727
  109. Conditions for activity of glutaminase in kidney mitochondria.
    Biochem J. 1970 Jun;118(2):265-74 PMID: 5530189
  110. Regulation of flux through glutaminase and glutamine synthetase in isolated perfused rat liver.
    Biochim Biophys Acta. 1983 Jan 25;755(2):272-8 PMID: 6131695
  111. The utilization of unesterified palmitate by Ehrlich ascites tumor cells.
    J Biol Chem. 1965 Oct;240(10):3747-53 PMID: 5891574
  112. A distinct Na+-requiring transport system for alanine, serine, cysteine, and similar amino acids.
    J Biol Chem. 1967 Nov 25;242(22):5237-46 PMID: 6070848
  113. The metabolic environment of cancer.
    Mol Cell Biochem. 1988 May;81(1):3-17 PMID: 3050448
  114. Malignancy and tissue metabolism.
    Nature. 1962 Dec 1;196:876-80 PMID: 13988711
  115. Azaserine, DON, and azotomycin: three diazo analogs of L-glutamine with clinical antitumor activity.
    Cancer Treat Rep. 1979 Jun;63(6):1033-8 PMID: 380801
  116. Enhancement of the sensitivity of human colon cancer cells to growth inhibition by acivicin achieved through inhibition of nucleic acid precursor salvage by dipyridamole.
    Cancer Res. 1984 Aug;44(8):3355-9 PMID: 6744269
  117. Cellular compartmentation of Ehrlich ascites tumor cells.
    Rev Esp Fisiol. 1984 Dec;40(4):405-10 PMID: 6531506
  118. Neoplastic transformation of newborn rat astrocytes in culture.
    Brain Res. 1985 Nov 25;348(1):21-7 PMID: 4063824
  119. Purification of phosphate-dependent glutaminase from isolated mitochondria of Ehrlich ascites-tumour cells.
    Biochem J. 1988 Nov 1;255(3):1031-5 PMID: 3214421
  120. Glutamine metabolism in the rat.
    FEBS Lett. 1980 Aug 25;117 Suppl:K86-92 PMID: 6106558
  121. Glutamine and glucose as energy substrates for Ehrlich ascites tumour cells.
    Biochem Int. 1988 Feb;16(2):339-47 PMID: 3365266
  122. Efficacy of 6-diazo-5-oxo-L-norleucine and N-[N-gamma-glutamyl-6-diazo-5-oxo-norleucinyl]-6-diazo-5-oxo-norleucine against experimental tumors in conventional and nude mice.
    Cancer Res. 1979 Aug;39(8):3220-4 PMID: 572261
  123. Mitochondrial metabolism of glutamine and glutamate and its physiological significance.
    Physiol Rev. 1983 Apr;63(2):547-605 PMID: 6132422
  124. Effect of palmitate, acetate and glucose on glutamine metabolism in Ehrlich ascites tumor cells.
    Biochimie. 1988 Jun;70(6):833-4 PMID: 3139099
  125. The metabolic fate of 13N-labeled ammonia in rat brain.
    J Biol Chem. 1979 Jun 25;254(12):4982-92 PMID: 36379
  126. Early development of protein metabolic perturbations in the liver and skeletal muscle of tumour-bearing rats. A model system for cancer cachexia.
    Biochem J. 1987 Jan 1;241(1):153-9 PMID: 3566707
  127. Kinetics of glutamine-efflux from liver mitochondria loaded with the 14C-Labeled substrate.
    Biochim Biophys Acta. 1982 May 7;687(2):291-5 PMID: 7093259
  128. Substrate-specificity of glutamine transporters in membrane vesicles from rat liver and skeletal muscle investigated using amino acid analogues.
    Biochem J. 1991 Aug 15;278 ( Pt 1):105-11 PMID: 1883322
  129. 31P-NMR studies of glucose and glutamine metabolism in cultured mammalian cells.
    Biochim Biophys Acta. 1990 Feb 19;1051(2):131-7 PMID: 2310767
  130. Effects of the combination of acivicin and cis-diamminedichloroplatinum(II) on thymidylate synthesis of A549 lung cancer cells.
    Biochem Biophys Res Commun. 1989 May 30;161(1):31-7 PMID: 2730661
  131. Phase I and pharmacokinetic studies of DON.
    Cancer Treat Rep. 1981 Nov-Dec;65(11-12):1031-6 PMID: 7296548
  132. Glutamine metabolism in Ehrlich ascites-carcinoma cells.
    Biochem J. 1962 May;83:284-91 PMID: 13880493
  133. Nitrogen metabolism in tumor bearing mice.
    Arch Biochem Biophys. 1989 Feb 1;268(2):667-75 PMID: 2913952
  134. The enzymic pattern of neoplastic tissue.
    Adv Cancer Res. 1967;10:117-61 PMID: 4862935
  135. Fatty acid oxidation to H2O by Ehrlich ascites carcinoma in mice.
    Cancer Res. 1979 Mar;39(3):973-80 PMID: 427783
  136. Inhibition of tumor cell glutamine uptake by isolated neutrophils.
    J Clin Invest. 1988 Sep;82(3):789-96 PMID: 2843571
  137. Nitrogen movement between host and tumor in mice inoculated with Ehrlich ascitic tumor cells.
    Cancer Res. 1984 Sep;44(9):3831-5 PMID: 6146402
Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
Published
1992-07-06
Pages
1-15
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]