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PMID: 16413919 Published · ppublish English Comment Journal Article

IL-1 can act as number one.

Immunity ·Vol. 24 ·No. 1 ·2006-01-00 ·Pages 16-7

Gamero AM, Oppenheim JJ

Abstract

Both interleukin-1 receptor (IL-1R) and toll-like receptor 2 (TLR2) signal via the adapter molecule MyD88. However, in response to a cutaneous infection challenge, the downstream signaling events diverge and IL-1R, but not TLR2, proves to be essential for host defense.

MeSH Terms
Adaptor Proteins, Signal Transducing/genetics,metabolism Animals Interleukin-1/metabolism Mice Myeloid Differentiation Factor 88 Receptors, Interleukin-1/genetics,metabolism Staphylococcal Infections/genetics,immunology Staphylococcus aureus
Chemicals
Adaptor Proteins, Signal Transducing Interleukin-1 Myd88 protein, mouse Myeloid Differentiation Factor 88 Receptors, Interleukin-1
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Gamero Ana M
Laboratory of Experimental Immunology, Center for Cancer Research, National Cancer Institute, FCRF, Frederick, Maryland 21702, USA.
Oppenheim Joost J
Article Info
Journal
Immunity
Abbr.
Immunity
ISSN
1074-7613
DOI
10.1016/j.immuni.2005.12.007
Published
2006-01-00
Pages
16-7
Language
English
Region
United States
NLM ID
9432918
Subset
IM
Corrections
CommentOn
PMID: 16413925
External Links
PubMed source DOI: 10.1016/j.immuni.2005.12.007 View journal details
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