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PMID: 16432150 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The ubiquitin proteolytic system: from a vague idea, through basic mechanisms, and onto human diseases and drug targeting.

Neurology ·Vol. 66 ·No. 2 Suppl 1 ·2006-01-24 ·Pages S7-19

Ciechanover A

Abstract

暂无摘要

MeSH Terms

Animals Drug Design Endopeptidases/metabolism Female Humans Inflammation/metabolism Male Mammals/metabolism Models, Biological Neoplasms/metabolism Neurodegenerative Diseases/metabolism Proteasome Endopeptidase Complex/metabolism Protein Processing, Post-Translational Proteins/metabolism Substrate Specificity Ubiquitin/physiology Ubiquitin-Activating Enzymes/metabolism

Chemicals

Proteins Ubiquitin Endopeptidases Proteasome Endopeptidase Complex ATP dependent 26S protease Ubiquitin-Activating Enzymes

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Ciechanover Aaron

Vascular and Tumor Biology Research Center, Faculty of Medicine, The Rappaport Faculty of Medicine and Research Institute, Technion-Israel Institute of Technology, Haifa, Israel. [email protected]

Article Info

Journal

Neurology

Abbr.

Neurology

ISSN

1526-632X

DOI

10.1212/01.wnl.0000192261.02023.b8

[email protected]

Published

2006-01-24

Pages

S7-19

Language

English

Region

United States

NLM ID

0401060

Subset

External Links

PubMed source DOI: 10.1212/01.wnl.0000192261.02023.b8 View journal details

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The ubiquitin proteolytic system: from a vague idea, through basic mechanisms, and onto human diseases and drug targeting.

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