Home LiteratureArticle Details
PMID: 164619 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

The mechanism of lipid-binding by plasma lipoproteins.

Molecular and cellular biochemistry ·Vol. 6 ·No. 1 ·1975-01-31 ·Pages 43-50

Jackson RL, Morrisett JD, Gotto AM, Segrest JP

Abstract

In this article, we review the current state of knowledge about the structure of human plasma high density lipoproteins. Recent advances in this field, including amino acid sequencing and lipid-binding studies, suggest that the plasma lipoproteins have specific sites with special structural features that account for their ability to bind and transport lipid. A hypothesis which describes the structure of these lipid-binding sites and their interaction with lipid is presented.

MeSH Terms
Amino Acids/analysis Apoproteins Binding Sites Humans Lipoproteins, HDL/blood Macromolecular Substances Models, Molecular Molecular Weight Phosphatidylcholines Phosphatidylethanolamines Phospholipids Protein Binding Protein Conformation
Chemicals
Amino Acids Apoproteins Lipoproteins, HDL Macromolecular Substances Phosphatidylcholines Phosphatidylethanolamines Phospholipids
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Jackson R L
Morrisett J D
Gotto A M
Segrest J P
References (41)
41 references, click to expand
  1. Isolation and characterization of apoLp-Gln-II (apoA-II), a plasma high density apolipoprotein containing two identical polypeptide chains.
    J Biol Chem. 1972 Dec 10;247(23):7510-8 PMID: 4344224
  2. Human high density lipoprotein, apolipoprotein glutamine II. The immunochemical and lipid-binding properties of apolipoprotein glutamine II derivatives.
    J Biol Chem. 1973 Aug 10;248(15):5218-24 PMID: 4358608
  3. Fractionation of human serum high density lipoprotein in urea solutions. Evidence for polypeptide heterogeneity.
    Biochemistry. 1969 Aug;8(8):3309-16 PMID: 4980192
  4. A molecular theory of lipid-protein interactions in the plasma lipoproteins.
    FEBS Lett. 1974 Jan 15;38(3):247-58 PMID: 4368333
  5. Studies of the proteins in human plasma very low density lipoproteins.
    J Biol Chem. 1969 Oct 25;244(20):5687-94 PMID: 4981584
  6. Structure of human serum lipoproteins.
    Ann N Y Acad Sci. 1972 Jun 20;195:390-406 PMID: 4338421
  7. On the subunit structure of the protein of human serum high density lipoprotein. I. A study of its major polypeptide component (Sephadex, fraction 3).
    J Biol Chem. 1972 Sep 25;247(18):5842-9 PMID: 4341494
  8. Molecular structure of serum lipoproteins.
    J Theor Biol. 1969 Jun;23(3):387-99 PMID: 5806621
  9. The influence of lipid on the conformation of human plasma high density apolipoproteins.
    J Biol Chem. 1972 Apr 25;247(8):2598-606 PMID: 4336379
  10. Molecular weight and subunit structure of human serum high density lipoproteinafter chemical modifications by succinic anhydride.
    Biochim Biophys Acta. 1968 May 6;160(1):32-45 PMID: 5651693
  11. The structure of human density lipoprotein: a study of the effect of phospholipase A and trypsin on its components and of the behavior of the lipid and protein moieties at the air-water interphase.
    Biochim Biophys Acta. 1969 Mar;175(2):290-300 PMID: 5778170
  12. The primary structure of high density apolipoprotein-glutamine-I.
    Proc Natl Acad Sci U S A. 1974 Sep;71(9):3631-4 PMID: 4372630
  13. Heterogeneity in protein subunits of human serum high-density lipoproteins.
    Biochemistry. 1968 Aug;7(8):2773-7 PMID: 5666751
  14. The primary structure of apolopoprotein-serine.
    J Biol Chem. 1974 Aug 25;249(16):5308-13 PMID: 4369340
  15. The metabolism of very low density lipoprotein proteins. II. Studies on the transfer of apoproteins between plasma lipoproteins.
    Biochim Biophys Acta. 1972 Sep 7;280(1):94-104 PMID: 4341829
  16. Conformation of human serum high density lipoprotein and its peptide components.
    Nature. 1969 Oct 4;224(5214):69-70 PMID: 5822907
  17. Isolation of a helical, lipid-binding fragment from the human plasma high density lipoprotein, apoLP GLN-I.
    Biochem Biophys Res Commun. 1972 Dec 18;49(6):1444-51 PMID: 4344811
  18. Small angle X-ray scattering of LpA, the major lipoprotein family of human plasma high density lipoprotein HDL(3).
    FEBS Lett. 1972 Oct 15;27(1):53-57 PMID: 11946806
  19. Interaction of phosphatidylcholine and apolipoprotein-alanine: electron microscopic studies.
    Biochim Biophys Acta. 1973 Mar 8;296(3):653-60 PMID: 4688643
  20. Identification of the lipid-binding cyanogen bromide fragment from the cystine-containing high density apolipoprotein, APOLP-GLN-II.
    Biochem Biophys Res Commun. 1972 Oct 6;49(1):23-9 PMID: 4342724
  21. Reassembly in vitro of a serum high-density lipoprotein.
    Biochim Biophys Acta. 1970 May 26;207(2):364-7 PMID: 4989610
  22. Chemical synthesis and biochemical properties of peptide fragments of apolipoprotein-alanine.
    Proc Natl Acad Sci U S A. 1973 Jul;70(7):2124-8 PMID: 4352973
  23. Apoliproproteins and lipoproteins.
    Atherosclerosis. 1971 Mar-Apr;13(2):141-6 PMID: 5560875
  24. The interaction of apolipoprotein-serine with phosphatidylcholine.
    J Biol Chem. 1974 Aug 25;249(16):5314-20 PMID: 4369320
  25. Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein isolated from the high-density lipoprotein complex.
    Proc Natl Acad Sci U S A. 1972 May;69(5):1304-8 PMID: 4338591
  26. Human plasma high density lipoprotein. Interaction of the cyanogen bromide fragments from apolipoprotein glutamine II (A-II) with phosphatidylcholine.
    J Biol Chem. 1973 Dec 25;248(24):8449-56 PMID: 4357738
  27. On the structure of human serum low density lipoprotein.
    J Mol Biol. 1972 Sep 14;70(1):105-16 PMID: 4342194
  28. Studies on the structure of lipoprotein A of human high density lipoprotein HDL3: the spherically averaged electron density distribution.
    FEBS Lett. 1973 Jun 15;33(1):77-80 PMID: 4352937
  29. X-ray small angle scattering of human plasma high density lipoprotein LpA from HDL2: application of a new evaluation method.
    FEBS Lett. 1974 Mar 15;40(1):213-8 PMID: 4369448
  30. Combination of delipidized high density lipoprotein with lipids.
    J Biol Chem. 1967 Mar 25;242(6):1205-10 PMID: 4164658
  31. Interaction of an apolipoprotein (apoLP-alanine) with phosphatidylcholine.
    Biochemistry. 1973 Mar 27;12(7):1290-9 PMID: 4348832
  32. Precipitation of 125 I-labeled lipoproteins with specific polypeptide antisera. Evidence for two populations with differing polypeptide compositions in human high density lipoproteins.
    Biochemistry. 1971 Aug 31;10(18):3436-42 PMID: 5000816
  33. Studies of the composition and structure of plasma lipoproteins. C- and N-terminal amino acids of the two nonidentical polypeptides of human plasma apolipoprotein A.
    FEBS Lett. 1971 Jul 1;15(4):320-324 PMID: 11945874
  34. A protein cofactor of lecithin:cholesterol acyltransferase.
    Biochem Biophys Res Commun. 1972 Feb 25;46(4):1493-8 PMID: 4335615
  35. Further characterization of apolipoproteins from the human plasma very low density lipoproteins.
    J Biol Chem. 1970 Dec 25;245(24):6588-94 PMID: 5482770
  36. Exchange of phospholipids between low and high density lipoproteins of squirrel monkeys.
    J Lipid Res. 1972 Mar;13(2):220-7 PMID: 4335797
  37. THE ACTION OF ENZYMES OF HUMAN ALPHA-LIPOPROTEIN.
    Biochem J. 1963 Dec;89:561-4 PMID: 14101977
  38. Degradation and reassembly of a human serum high-density lipoprotein. Evidence for differences in lipid affinity among three classes of polypeptide chains.
    Biochemistry. 1970 Mar 17;9(6):1327-35 PMID: 4984905
  39. Application of electron microscopy to the study of plasma lipoprotein structure.
    Adv Lipid Res. 1972;10:1-41 PMID: 4344798
  40. The apolipoproteins.
    Adv Exp Med Biol. 1972;26(0):25-56 PMID: 4370434
  41. Isolation and characterization of the tryptic and cyanogen bromide peptides of apoLp-Gln-II (apoA-II), plasma high density apolipoprotein.
    J Biol Chem. 1972 Dec 10;247(23):7519-27 PMID: 4344225
Article Info
Journal
Molecular and cellular biochemistry
Abbr.
Mol Cell Biochem
ISSN
0300-8177
DOI
10.1007/BF01731865
Published
1975-01-31
Pages
43-50
Language
English
Region
Netherlands
NLM ID
0364456
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01731865 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2