Home LiteratureArticle Details
PMID: 164657 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Regulation of development in Myxococcus xanthus: effect of 3':5'-cyclic AMP, ADP, and nutrition.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 72 ·No. 2 ·1975-02-00 ·Pages 518-22

Campos JM, Zusman DR

Abstract

An assay was developed to study the regulation of fruiting in Myxococcus xanthus. The nucleotides, adenosine 3':5'-cyclic monophosphate (cyclic AMP) and adenosine diphosphate (ADP), were found to greatly stimulate fruiting under the assay conditions. Very sharp concentration optima were observed. Even under conditions of starvation, these nucleotides greatly increased the number of aggregation sites. Nutrition was found to influence fruiting body morphology. The effect of amino acids on the nucleotide stimulation of fruiting was studied under our assay conditions. L-Methionine and L-isoleucine (1 mM) completely blocked either L-threonine or D,L-diaminopimelic acid synergistically enhanced the amount of fruiting in the presence of these nucleotides. The data presented suggest the existence of differentiation-related regulatory compounds in M. xanthus.

MeSH Terms
Adenosine Diphosphate/pharmacology Adenosine Monophosphate/pharmacology Amino Acids/metabolism,pharmacology Cyclic AMP/pharmacology Myxococcales/drug effects,growth & development,metabolism
Chemicals
Amino Acids Adenosine Monophosphate Adenosine Diphosphate Cyclic AMP
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Campos J M
Zusman D R
References (8)
8 references, click to expand
  1. NUTRITIONAL REGU.ATION OF MORPHOGENESIS IN MYXOCOCCUS XANTHUS.
    J Bacteriol. 1963 Jul;86:67-72 PMID: 14051824
  2. Adenosine-3',5'-phosphate: identification as acrasin in a species of cellular slime mold.
    Science. 1969 Sep 12;165(3898):1133-4 PMID: 4308325
  3. Aspartokinase of Myxococcus xanthus: "feedback stimulation" by required amino acids.
    J Bacteriol. 1973 Jul;115(1):23-8 PMID: 4717514
  4. Aspartokinase activity and the developmental cycle of Myxococcus xanthus.
    J Bacteriol. 1973 Jul;115(1):29-34 PMID: 4717518
  5. The acrasin activity of adenosine-3',5'-cyclic phosphate.
    Proc Natl Acad Sci U S A. 1967 Sep;58(3):1152-4 PMID: 4861307
  6. Regulation of aspartokinase in Bacillus subtilis. The separation and properties of two isofunctional enzymes.
    J Biol Chem. 1971 May 10;246(9):2965-71 PMID: 4995121
  7. Biology of the myxobacteria.
    Annu Rev Microbiol. 1966;20:75-106 PMID: 5330241
  8. Nutritional induction and suppression of fruiting in Myxococcus xanthus FBa.
    J Bacteriol. 1968 Mar;95(3):1018-23 PMID: 5643044
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.72.2.518
Published
1975-02-00
Pages
518-22
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC432343
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.72.2.518 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2