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PMID: 1647421 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Evaluation of the effect of drugs on the cyst form of Toxoplasma gondii.

The Journal of infectious diseases ·Vol. 164 ·No. 1 ·1991-07-00 ·Pages 170-1

Huskinson-Mark J, Araujo FG, Remington JS

Abstract

The cyst form of Toxoplasma gondii has been implicated as a cause of recrudescence of the latent infection in congenitally infected patients and in the immunocompromised host. A method was developed to evaluate the effect of drugs on the cyst form of the parasite and used to evaluate a variety of therapeutic agents. The most active compounds against the cyst form in vitro were arprinocid-N-oxide, azithromycin, and the hydroxynaphthoquinone 566C80.

MeSH Terms
Adenine/analogs & derivatives,pharmacology Animals Anti-Infective Agents/pharmacology Atovaquone Azithromycin Brain/parasitology Clindamycin/pharmacology Coccidiostats/pharmacology Erythromycin/analogs & derivatives,pharmacology Fluorouracil/pharmacology Mice Mice, Inbred CBA Naphthoquinones/pharmacology Pyrimethamine/pharmacology Sulfadiazine/pharmacology Toxoplasma/drug effects
Chemicals
Anti-Infective Agents Coccidiostats Naphthoquinones Sulfadiazine Clindamycin arprinocid-N-oxide Erythromycin Azithromycin Adenine Fluorouracil Atovaquone Pyrimethamine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Huskinson-Mark J
Department of Immunology and Infectious Diseases, Palo Alto Medical Foundation, CA 94301.
Araujo F G
Remington J S
Article Info
Journal
The Journal of infectious diseases
Abbr.
J Infect Dis
ISSN
0022-1899
DOI
10.1093/infdis/164.1.170
Published
1991-07-00
Pages
170-1
Language
English
Region
United States
NLM ID
0413675
Subset
IM
Grants
NIAID NIH HHS · AI-30230 · United States
NIAID NIH HHS · AI-74717 · United States
External Links
PubMed source DOI: 10.1093/infdis/164.1.170 View journal details
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