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PMID: 1648733 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The subtypes of the mouse inositol 1,4,5-trisphosphate receptor are expressed in a tissue-specific and developmentally specific manner.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 88 ·No. 14 ·1991-07-15 ·Pages 6244-8

Nakagawa T, Okano H, Furuichi T, Aruga J, Mikoshiba K

Abstract

Additional subtypes of the inositol 1,4,5-trisphosphate (InsP3) receptor are expressed in a tissue-specific and developmentally specific manner. They differ from the InsP3 receptor structure previously reported in two small variably spliced segments. One segment (SI) is located within the InsP3 binding site, whereas another segment (SII) is located near putative sites for phosphorylation and ATP binding to modulate InsP3 action on Ca2+ flux. Therefore, we speculate that selective use of InsP3 receptor subtypes permits a tissue-specific and developmentally specific expression of functionally distinct channels.

MeSH Terms
Aging/physiology Amino Acid Sequence Animals Base Sequence Brain/growth & development Calcium Channels DNA/genetics,isolation & purification Inositol 1,4,5-Trisphosphate/metabolism Inositol 1,4,5-Trisphosphate Receptors Male Mice Mice, Inbred ICR Molecular Sequence Data Organ Specificity Polymerase Chain Reaction/methods RNA, Messenger/analysis,genetics Receptors, Cell Surface/genetics,metabolism Receptors, Cytoplasmic and Nuclear Restriction Mapping Spinal Cord/growth & development
Chemicals
Calcium Channels Inositol 1,4,5-Trisphosphate Receptors RNA, Messenger Receptors, Cell Surface Receptors, Cytoplasmic and Nuclear Inositol 1,4,5-Trisphosphate DNA
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Nakagawa T
Division of Regulation of Macromolecular Function, Osaka University, Suita, Japan.
Okano H
Furuichi T
Aruga J
Mikoshiba K
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.88.14.6244
Published
1991-07-15
Pages
6244-8
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC52059
Subset
IM
Databases
GENBANK
M60982, M60983, M60984, M60985, M60986, M60987, M60988, M64661, M75986, M75987
External Links
PubMed source DOI: 10.1073/pnas.88.14.6244 PMC Full Text View journal details
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