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PMID: 16488176 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Exploring the ESCRTing machinery in eukaryotes.

Trends in plant science ·Vol. 11 ·No. 3 ·2006-03-00 ·Pages 115-23

Winter V, Hauser MT

Abstract

The profile of protein sorting into multivesicular bodies (MVBs) has risen recently with the identification of three heteromeric complexes known as ESCRT-I,-II,-III (Endosomal Sorting Complex Required for Transport). Genetic analyses in yeast have identified up to 15 soluble class E VPS (vacuolar protein sorting) proteins that have been assigned to the ESCRT machinery and function in cargo recognition and sorting, complex assembly, vesicle formation and dissociation. Despite their functional importance in yeast and mammalian cells, little is known about their presence and function in other organisms including plants. We have made use of the fully sequenced genomes of Arabidopsis thaliana and Oryza sativa, Drosophila melanogaster and Caenorhabditis elegans to explore the identity, structural characteristics and phylogenetic relationships of proteins assigned to the ESCRT machinery.

MeSH Terms
Animals Carrier Proteins/genetics,physiology Endosomes/metabolism Eukaryotic Cells/metabolism Humans Multiprotein Complexes/genetics,physiology Phylogeny Plants/genetics,metabolism Protein Transport
Chemicals
Carrier Proteins Multiprotein Complexes
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Winter Verena
Institute of Applied Genetics and Cell Biology, Department of Applied Plant Sciences and Plant Biotechnology, BOKU - University of Natural Resources and Applied Life Sciences, Vienna, Austria.
Hauser Marie-Theres
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Article Info
Journal
Trends in plant science
Abbr.
Trends Plant Sci
ISSN
1360-1385
DOI
10.1016/j.tplants.2006.01.008
Published
2006-03-00
Epub
2006-00-20
Pages
115-23
Language
English
Region
England
NLM ID
9890299
PMCID
PMC2865992
Subset
IM
Grants
Austrian Science Fund FWF · P 16410 · Austria
External Links
PubMed source DOI: 10.1016/j.tplants.2006.01.008 PMC Full Text View journal details
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