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PMID: 16552047 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Correlation between eosinophils and protection against reinfection with Schistosoma mansoni and the effect of human immunodeficiency virus type 1 coinfection in humans.

Infection and immunity ·Vol. 74 ·No. 4 ·2006-04-00 ·Pages 2169-76

Ganley-Leal LM, Mwinzi PN, Cetre-Sossah CB, Andove J, Hightower AW, Karanja DM, Colley DG, Secor WE

Abstract

Longitudinal investigations of an adult male population of Kenyan car washers who have heavy and quantifiable occupational exposure to Schistosoma mansoni cercariae revealed that some individuals develop resistance to reinfection while others remain highly susceptible. We sought to characterize immune correlates associated with host protection in this population. Previous studies have demonstrated an association of peripheral eosinophilia with resistance to reinfection with schistosomes. Thus, we investigated the relationship between the percentage of circulating eosinophils and the effect of human immunodeficiency virus type 1 (HIV-1) coinfection on the susceptibility of the car washers to reinfection with schistosomes. Elevated percentages of circulating eosinophils were associated with resistance to reinfection by S. mansoni in HIV-1-seronegative persons. In the HIV-1-seropositive cohort, low CD4+-T-cell counts were associated with a less intense eosinophilia. Moreover, eosinophils from the car washers expressed high levels of FcepsilonRI beta chain, a molecule important in immunoglobulin E (IgE)-mediated immunity. Levels of FcepsilonRI beta chain expression correlated with serum levels of total and antigen-specific IgE for HIV-1-negative car washers, but this was not the case for individuals coinfected with HIV-1. Overall, these data further implicate eosinophils as having a potential role in development of protective immunity against schistosomes and suggest that changes associated with HIV-1 coinfection increase susceptibility to reinfection.

MeSH Terms
Adolescent Adult Animals CD4-Positive T-Lymphocytes/immunology Cells, Cultured Eosinophilia/immunology Eosinophils/immunology,metabolism HIV Infections/immunology,parasitology HIV-1/immunology Humans Immunoglobulin E/blood Interleukin-5/biosynthesis Leukocyte Count Male Middle Aged Receptors, IgE/biosynthesis,blood,genetics Schistosoma mansoni/immunology Schistosomiasis mansoni/immunology,prevention & control,virology Secondary Prevention
Chemicals
Interleukin-5 MS4A2 protein, human Receptors, IgE Immunoglobulin E
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Ganley-Leal Lisa M
Centers for Disease Control and Prevention, Division of Parasitic Diseases, 4770 Buford Hwy, N.E., Atlanta, GA 30341, USA.
Mwinzi Pauline N
Cetre-Sossah Catherine B
Andove Julius
Hightower Allen W
Karanja Diana M S
Colley Daniel G
Secor W Evan
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/IAI.74.4.2169-2176.2006
Published
2006-04-00
Pages
2169-76
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC1418888
Subset
IM
Grants
NIAID NIH HHS · R01 AI053695 · United States
NIAID NIH HHS · T32 AI052070 · United States
NIAID NIH HHS · AI053695 · United States
NIAID NIH HHS · T32 AI52070 · United States
External Links
PubMed source DOI: 10.1128/IAI.74.4.2169-2176.2006 PMC Full Text View journal details
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