The KEOPS complex: a rosetta stone for telomere regulation?

Cell ·Vol. 124 ·No. 6 ·2006-03-24 ·Pages 1125-8

Bianchi A, Shore D

Abstract

The detailed mechanisms underlying telomere capping and its relationship to telomerase activity are still unclear, although many proteins have been implicated in either or both processes. In this issue of Cell, the surprising identification of a new complex, called KEOPS, which promotes both telomere uncapping and elongation is presented.

MeSH Terms

Gene Expression Regulation, Enzymologic Macromolecular Substances/metabolism Telomerase/genetics,physiology Telomere/physiology

Chemicals

Macromolecular Substances Telomerase

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Bianchi Alessandro

Department of Molecular Biology and NCCR Program "Frontiers in Genetics," University of Geneva, Sciences III, 30, Quai Ernest-Ansermet, CH-1211, Geneva 4, Switzerland.

Shore David

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/j.cell.2006.03.008

Published

2006-03-24

Pages

1125-8

Language

English

Region

United States

NLM ID

0413066

Subset

Corrections

CommentOn

PMID: 16564010

External Links

PubMed source DOI: 10.1016/j.cell.2006.03.008 View journal details

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The KEOPS complex: a rosetta stone for telomere regulation?

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