The ins and outs of iron homeostasis.

Physiology (Bethesda, Md.) ·Vol. 21 ·2006-04-00 ·Pages 115-23

Donovan A, Roy CN, Andrews NC

Abstract

Iron is an essential element that is toxic when it accumulates in excess. Intricate regulatory mechanisms have evolved to maintain iron homeostasis within cells and between different tissues of complex organisms. This review discusses the proteins involved in iron transport and storage and their regulation in health and disease.

MeSH Terms

Animals Antimicrobial Cationic Peptides/physiology Cation Transport Proteins/physiology Hepcidins Homeostasis/physiology Humans Intestinal Mucosa/metabolism Iron/metabolism Iron Metabolism Disorders/etiology,physiopathology Iron Overload/etiology,physiopathology Iron-Regulatory Proteins/physiology

Chemicals

Antimicrobial Cationic Peptides Cation Transport Proteins Hepcidins Iron-Regulatory Proteins metal transporting protein 1 Iron

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Donovan Adriana

Children's Hospital Boston, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

Roy Cindy N

Andrews Nancy C

Article Info

Journal

Physiology (Bethesda, Md.)

Abbr.

Physiology (Bethesda)

ISSN

1548-9213

DOI

10.1152/physiol.00052.2005

Published

2006-04-00

Pages

115-23

Language

English

Region

United States

NLM ID

101208185

Subset

External Links

PubMed source DOI: 10.1152/physiol.00052.2005 View journal details

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