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PMID: 1656693 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Ca2+/calmodulin-dependent protein kinase II immunoreactivity in Lewy bodies.

Acta neuropathologica ·Vol. 82 ·No. 3 ·1991-00-00 ·Pages 159-63

Iwatsubo T, Nakano I, Fukunaga K, Miyamoto E

Abstract

Ca2+/calmodulin-dependent protein kinase II (CaM kinase II) is one of the predominant protein kinases in the brain. We found that CaM kinase II immunoreactivity was concentrated in the peripheral halos of Lewy bodies (LBs) in Parkinson's disease and Lewy body-like hyaline inclusions (LBHIs) in amyotrophic lateral sclerosis. An immunoelectron microscopic examination of LBs revealed that the filaments at the periphery of LBs were decorated with immunopositive deposits. Since CaM kinase II has a broad substrate specificity and can phosphorylate neurofilaments and other cytoskeletal proteins, it may play some role in the formation of LBs and LBHIs through the aberrant phosphorylation of the cytoskeletal elements in these inclusions.

MeSH Terms
Aged Aged, 80 and over Brain/enzymology,pathology,ultrastructure Calcium-Calmodulin-Dependent Protein Kinases Female Humans Immunoenzyme Techniques Lewy Bodies/enzymology,ultrastructure Male Microscopy, Immunoelectron Parkinson Disease/enzymology,pathology Protein Kinases/analysis Reference Values Spinal Cord/enzymology,pathology,ultrastructure
Chemicals
Protein Kinases Calcium-Calmodulin-Dependent Protein Kinases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Iwatsubo T
Department of Neuropathology, Faculty of Medicine, University of Tokyo, Japan.
Nakano I
Fukunaga K
Miyamoto E
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Article Info
Journal
Acta neuropathologica
Abbr.
Acta Neuropathol
ISSN
0001-6322
DOI
10.1007/BF00294440
Published
1991-00-00
Pages
159-63
Language
English
Region
Germany
NLM ID
0412041
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00294440 View journal details
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