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PMID: 16570048 Published · ppublish English Journal Article Review Systematic Review

Adiponectin and cancer: a systematic review.

British journal of cancer ·Vol. 94 ·No. 9 ·2006-05-08 ·Pages 1221-5

Kelesidis I, Kelesidis T, Mantzoros CS

Abstract

Recent studies have demonstrated that obesity is a significant risk factor for the development of several malignancies, but the mechanisms underlying this relationship remain to be fully elucidated. Adiponectin, an adipocyte secreted endogenous insulin sensitizer, appears to play an important role not only in glucose and lipid metabolism but also in the development and progression of several obesity-related malignancies. In this review, we present recent findings on the association of adiponectin with several malignancies as well as recent data on underlying molecular mechanisms that provide novel insights into the association between obesity and cancer risk. We also identify important research questions that remain unanswered.

MeSH Terms
Adiponectin/physiology Endocrine System/physiology Glucose/metabolism Humans Lipid Metabolism Neoplasms/physiopathology Obesity/complications Receptors, Cell Surface Risk Factors
Chemicals
Adiponectin Receptors, Cell Surface Glucose
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kelesidis I
Division of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Kelesidis T
Mantzoros C S
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
DOI
10.1038/sj.bjc.6603051
Published
2006-05-08
Pages
1221-5
Language
English
Region
England
NLM ID
0370635
PMCID
PMC2361397
Subset
IM
External Links
PubMed source DOI: 10.1038/sj.bjc.6603051 PMC Full Text View journal details
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