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PMID: 1657417 Published · ppublish English Comparative Study Journal Article

Contrasting mutation rates in mitochondrial and nuclear genes of yeasts versus mammals.

Current genetics ·Vol. 20 ·No. 3 ·1991-08-00 ·Pages 195-8

Clark-Walker GD

Abstract

Base substitutions have been compared in two mitochondrial and two nuclear genes from three yeasts and three mammals. In yeasts, the two mitochondrial genes, cytochrome oxidase subunit 2 (COX2) and apocytochrome b (CYB), have fewer changes on a percentage basis than the nuclear-encoded cytochrome c (CYC) gene. By contrast, in mammals, the same mitochondrial genes have more mutations than CYC on a percentage basis. Sequence comparisons of the nuclear small-subunit ribosomal RNA (nSSU) gene shows that there are more substitutions per unit length in the three yeasts than in the three mammals. This result suggests that although the yeasts are more distantly related than the mammals, their mitochondrial genes have accumulated fewer changes.

Related Genes
COX2 CYB CYC nSSU
MeSH Terms
Amino Acid Sequence Animals Autoradiography Base Sequence Candida/genetics Cell Nucleus/metabolism Cytochrome c Group/genetics DNA, Fungal/genetics Genes, Fungal Kluyveromyces/genetics Mammals Mitochondria/metabolism Molecular Sequence Data Mutation Open Reading Frames Restriction Mapping Saccharomyces cerevisiae/genetics Sequence Homology, Nucleic Acid
Chemicals
Cytochrome c Group DNA, Fungal
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Clark-Walker G D
Research School of Biological Sciences, Australian National University, Canberra, A.C.T.
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39 references, click to expand
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Article Info
Journal
Current genetics
Abbr.
Curr Genet
ISSN
0172-8083
DOI
10.1007/BF00326232
Published
1991-08-00
Pages
195-8
Language
English
Region
United States
NLM ID
8004904
Subset
IM
Databases
GENBANK
S39723, S39727, S39777, S60919, S60920, X56695, X57267, X58150, X58249, X62725, X62800
External Links
PubMed source DOI: 10.1007/BF00326232 View journal details
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