Leucinopine, a characteristic compound of some crown-gall tumors.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 80 ·No. 12 ·1983-06-00 ·Pages 3573-6

Chang CC, Chen CM, Adams BR, Trost BM

Abstract

An unusual compound has been found in crowngall tumors induced by those Agrobacterium tumefaciens strains that utilize neither octopine nor nopaline. The compound has been isolated and shown by proton and carbon-13 NMR spectroscopy and by synthesis to be N(2)-(1,3-dicarboxypropyl)-L-leucine, which also exists in a cyclized (i.e., lactam) form. This compound, which we name "leucinopine," was not detected in octopine tumors, nopaline tumors, or the tumors induced by A. tumefaciens strains 181 and EU6.

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Chang C C

Biomedical Research Institute, University of Wisconsin-Parkside, Kenosha, Wisconsin 53141.

Chen C M

Adams B R

Trost B M

References (12)

12 references, click to expand

Agropine in "null-type" crown gall tumors: Evidence for generality of the opine concept.
Proc Natl Acad Sci U S A. 1980 May;77(5):2693-7 PMID: 16592823
Octopine synthase mRNA isolated from sunflower crown gall callus is homologous to the Ti plasmid of Agrobacterium tumefaciens.
Proc Natl Acad Sci U S A. 1982 Jan;79(1):86-90 PMID: 16593142
Crown gall disease and prospects for genetic manipulation of plants.
Science. 1982 Nov 26;218(4575):854-9 PMID: 17807126
[ON THE PRESENCE OF OCTINE IN CROWN-GALL].
C R Hebd Seances Acad Sci. 1964 Dec 21;259:4795-6 PMID: 14254937
A useful synthesis of nopaline, a crown gall tumor metabolite.
Biochem Biophys Res Commun. 1977 Apr 25;75(4):1066-70 PMID: 861025
A new amino acid derivative present in crown gall tumor tissue.
Biochem Biophys Res Commun. 1977 Feb 7;74(3):862-8 PMID: 843357
Utilization of octopine and nopaline by Agrobacterium.
J Bacteriol. 1973 Oct;116(1):378-83 PMID: 4745420
The genus Agrobacterium and plant tumorigenesis.
Annu Rev Microbiol. 1975;29:377-405 PMID: 1180518
Properties of D(+)-lysopine dehydrogenase from crown gall tumour tissue.
Biochim Biophys Acta. 1977 Dec 8;485(2):268-77 PMID: 21695
Stable incorporation of plasmid DNA into higher plant cells: the molecular basis of crown gall tumorigenesis.
Cell. 1977 Jun;11(2):263-71 PMID: 890735
Purification and characterization of the crown gall specific enzyme nopaline synthase.
Biochemistry. 1979 Aug 21;18(17):3755-60 PMID: 476084
Octopine and nopaline metabolism in Agrobacterium tumefaciens and crown gall tumor cells: role of plasmid genes.
J Bacteriol. 1977 Jan;129(1):101-7 PMID: 830636

Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.80.12.3573

Published

1983-06-00

Pages

3573-6

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC394091

External Links

PubMed source DOI: 10.1073/pnas.80.12.3573 PMC Full Text View journal details

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Leucinopine, a characteristic compound of some crown-gall tumors.

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