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PMID: 16595154 Published · ppublish English Journal Article Review

Principles: when there should be no difference--how to fail to reject the null hypothesis.

Trends in pharmacological sciences ·Vol. 27 ·No. 5 ·2006-05-00 ·Pages 274-8

Lew MJ

Abstract

It is common to perform experiments in which a 'success' is claimed when the null hypothesis is discarded. However, there is a category of experiment that has become important in which a success is when the null hypothesis is not rejected. Failing to discard the null hypothesis is different from proving it to be valid, a distinction that is particularly important in experiments in which any inadequacy of experimental design or implementation enhances the likelihood of a success. The appropriate analysis of such experiments tests for evidence of the validity of the null hypothesis rather than simply failing to find evidence against it.

MeSH Terms
Confidence Intervals Humans Monte Carlo Method Pharmacology/methods,trends Reproducibility of Results Research Design
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Lew Michael J
Department of Pharmacology, University of Melbourne, Parkville, Victoria 3010, Australia. [email protected]
Article Info
Journal
Trends in pharmacological sciences
Abbr.
Trends Pharmacol Sci
ISSN
0165-6147
Published
2006-05-00
Epub
2006-00-03
Pages
274-8
Language
English
Region
England
NLM ID
7906158
Subset
IM
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