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PMID: 1660054 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Detection of Epstein-Barr virus genomes in Hodgkin's disease: relation to age.

Journal of clinical pathology ·Vol. 44 ·No. 10 ·1991-10-00 ·Pages 844-8

Jarrett RF, Gallagher A, Jones DB, Alexander FE, Krajewski AS, Kelsey A, Adams J, Angus B, Gledhill S, Wright DH

Abstract

An investigation as to whether any particular subgroup of patients with Hodgkin's disease was particularly likely to be Epstein-Barr virus (EBV) genome positive was made on samples from 95 patients. These were grouped according to age and Hodgkin's disease subtype, and analysed using Southern blot analysis. Most samples from children or adults aged 50 years or over contained detectable EBV genomes; samples from young adults were only rarely positive. The differences in EBV positivity by age were highly significant, but there was no significant association between EBV and histological subtype after allowing for the effect of age. The results support the hypothesis that Hodgkin's disease in different age groups may have different aetiologies, and suggest that EBV does have a pathogenetic role in Hodgkin's disease in children and older age groups.

MeSH Terms
Adolescent Adult Age Factors Aged Aged, 80 and over Blotting, Southern Genes, Viral Herpesvirus 4, Human/genetics,isolation & purification Hodgkin Disease/microbiology,pathology Humans Lymph Nodes/microbiology Middle Aged Spleen/microbiology
Authors & Affiliations
10 authors, click to expand affiliations / ORCID
Jarrett R F
Department of Veterinary Pathology, University of Glasgow.
Gallagher A
Jones D B
Alexander F E
Krajewski A S
Kelsey A
Adams J
Angus B
Gledhill S
Wright D H
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Article Info
Journal
Journal of clinical pathology
Abbr.
J Clin Pathol
ISSN
0021-9746
DOI
10.1136/jcp.44.10.844
Published
1991-10-00
Pages
844-8
Language
English
Region
England
NLM ID
0376601
PMCID
PMC496672
Subset
IM
Corrections
CommentIn
PMID: 1313457
External Links
PubMed source DOI: 10.1136/jcp.44.10.844 PMC Full Text View journal details
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