Comparative proteomic analysis of neoplastic and non-neoplastic germ cell tissue.

Biological chemistry ·Vol. 387 ·No. 4 ·2006-04-00 ·Pages 437-40

Zimmermann U, Junker H, Krämer F, Balabanov S, Kleist B, Kammer W, Nordheim A, Walther R

Abstract

A comparative proteomic analysis of neoplastic versus non-neoplastic seminoma identified glutathione S-transferase M3 as a differentially expressed protein. This expression difference could also be observed at the mRNA level, implying neoplasm-associated alterations in transcriptional or post-transcriptional mechanisms.

MeSH Terms

Biomarkers/analysis,metabolism Electrophoresis, Gel, Two-Dimensional Gene Expression Regulation, Neoplastic Germ Cells/cytology,enzymology Glutathione Transferase/analysis,genetics,metabolism Humans Male Mass Spectrometry Proteomics RNA, Messenger/metabolism Seminoma/enzymology Testicular Neoplasms/enzymology Transcription, Genetic

Chemicals

Biomarkers RNA, Messenger GSTM3 protein, human Glutathione Transferase

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Zimmermann Uwe

Department of Urology, University of Greifswald, Fleischmannstr. 42-44, D-17487 Greifswald, Germany.

Junker Heike

Krämer Fabian

Balabanov Stefan

Kleist Britta

Kammer Winfried

Nordheim Alfred

Walther Reinhard

Article Info

Journal

Biological chemistry

Abbr.

Biol Chem

ISSN

1431-6730

DOI

10.1515/BC.2006.058

Published

2006-04-00

Pages

437-40

Language

English

Region

Germany

NLM ID

9700112

Subset

External Links

PubMed source DOI: 10.1515/BC.2006.058 View journal details

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Comparative proteomic analysis of neoplastic and non-neoplastic germ cell tissue.

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