Home LiteratureArticle Details
PMID: 16614226 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

A common genetic variant is associated with adult and childhood obesity.

Science (New York, N.Y.) ·Vol. 312 ·No. 5771 ·2006-04-14 ·Pages 279-83

Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, Illig T, Wichmann HE, Meitinger T, Hunter D, Hu FB, Colditz G, Hinney A, Hebebrand J, Koberwitz K, Zhu X, Cooper R, Ardlie K, Lyon H, Hirschhorn JN, Laird NM, Lenburg ME, Lange C, Christman MF

Abstract

Obesity is a heritable trait and a risk factor for many common diseases such as type 2 diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA samples from the Framingham Heart Study participants to identify a common genetic variant near the INSIG2 gene associated with obesity. We have replicated the finding in four separate samples composed of individuals of Western European ancestry, African Americans, and children. The obesity-predisposing genotype is present in 10% of individuals. Our study suggests that common genetic polymorphisms are important determinants of obesity.

MeSH Terms
Adult African Americans Alleles Body Mass Index Case-Control Studies Child Cohort Studies Europe Female Gene Frequency Genes, Recessive Genetic Predisposition to Disease Genetic Variation Genotype Haplotypes Humans Intracellular Signaling Peptides and Proteins/genetics Linkage Disequilibrium Male Membrane Proteins/genetics Models, Genetic Obesity/genetics Oligonucleotide Array Sequence Analysis Polymorphism, Single Nucleotide Whites
Chemicals
INSIG2 protein, human Intracellular Signaling Peptides and Proteins Membrane Proteins
Authors & Affiliations
23 authors, click to expand affiliations / ORCID
Herbert Alan
Department of Genetics and Genomics, Boston University Medical School, E613, 715 Albany Street, Boston, MA 02118, USA. [email protected]
Gerry Norman P
McQueen Matthew B
Heid Iris M
Pfeufer Arne
Illig Thomas
Wichmann H-Erich
Meitinger Thomas
Hunter David
Hu Frank B
Colditz Graham
Hinney Anke
Hebebrand Johannes
Koberwitz Kerstin
Zhu Xiaofeng
Cooper Richard
Ardlie Kristin
Lyon Helen
Hirschhorn Joel N
Laird Nan M
Lenburg Marc E
Lange Christoph
Christman Michael F
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
1095-9203
DOI
10.1126/science.1124779
Email
[email protected]
Published
2006-04-14
Pages
279-83
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NHLBI NIH HHS · R01HL54485 · United States
NIDDK NIH HHS · P30DK46200 · United States
NICHD NIH HHS · R01 HD060726 · United States
NIDDK NIH HHS · K23DK067288 · United States
NHLBI NIH HHS · U01HL65899 · United States
NIGMS NIH HHS · R01GM046877 · United States
NHLBI NIH HHS · R01HL074166 · United States
NHLBI NIH HHS · R01HL66289 · United States
NIMH NIH HHS · R01MH59532 · United States
NCI NIH HHS · CA87969 · United States
NHLBI NIH HHS · U01 HL065899 · United States
Corrections
CommentIn
PMID: 17218508
CommentIn
PMID: 17218509
CommentIn
PMID: 17218510
External Links
PubMed source DOI: 10.1126/science.1124779 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2