A monotopic membrane protein goes solo.

Structure (London, England : 1993) ·Vol. 14 ·No. 4 ·2006-04-00 ·Pages 628-9

Mattevi A

Abstract

Carnitine palmitoyltransferases (CPTs) are part of the enzymatic system that imports fatty acids into mitochondria. The crystal structure of rat CPT-2 by Rufer et al. (2006) (this issue of Structure) reveals a Y-shaped tunnel for binding the CoA and acyl-carnitine substrates and a hydrophobic insert mediating membrane association.

MeSH Terms

Animals Binding Sites Carnitine/analogs & derivatives,chemistry Carnitine O-Palmitoyltransferase/chemistry,metabolism Catalysis Cell Membrane/chemistry Coenzyme A/chemistry Crystallography, X-Ray Escherichia coli/metabolism Fatty Acids/metabolism Lipid Bilayers/chemistry Molecular Conformation Protein Binding Protein Conformation Protein Structure, Tertiary Rats Recombinant Proteins/chemistry Solubility Substrate Specificity

Chemicals

Fatty Acids Lipid Bilayers Recombinant Proteins acylcarnitine Carnitine O-Palmitoyltransferase Carnitine Coenzyme A

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Mattevi Andrea

Article Info

Journal

Structure (London, England : 1993)

Abbr.

Structure

ISSN

0969-2126

DOI

10.1016/j.str.2006.03.002

Published

2006-04-00

Pages

628-9

Language

English

Region

United States

NLM ID

101087697

Subset

Corrections

CommentOn

PMID: 16615913

External Links

PubMed source DOI: 10.1016/j.str.2006.03.002 View journal details

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