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PMID: 16624920 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The hitchhiking effect of an autosomal meiotic drive gene.

Genetics ·Vol. 173 ·No. 3 ·2006-07-00 ·Pages 1829-32

Chevin LM, Hospital F

Abstract

Transmission-ratio distortion is a departure from a 1:1 segregation of alleles in the gametes of a heterozygous individual. The so-called driving allele is strongly selected regardless of its effect on the fitness of the carrying individual. It may then have an important impact on neutral polymorphism due to the genetic hitchhiking effect. We study this hitchhiking effect in the case of true meiotic drive in autosomes and show that it is more dependent on the recombination rate than in the classical case of a gene positively selected at the organism level.

MeSH Terms
Alleles Animals Chromosome Segregation Drosophila melanogaster/genetics Heterozygote Inheritance Patterns Meiosis Models, Genetic Polymorphism, Genetic Recombination, Genetic
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Chevin Luis-Miguel
UMR de Génétique Végétale du Moulon, INRA/Université Paris XI/CNRS/INA P-G, 91190 Gif-sur-Yvette, France. [email protected]
Hospital Frédéric
References (24)
24 references, click to expand
  1. Transmission ratio distortion in intraspecific hybrids of Mimulus guttatus: implications for genomic divergence.
    Genetics. 2005 May;170(1):375-86 PMID: 15781698
  2. Meiotic drive and sex chromosome cycling.
    Evolution. 2004 May;58(5):925-31 PMID: 15212373
  3. Maternal transmission ratio distortion at the mouse Om locus results from meiotic drive at the second meiotic division.
    Genetics. 2005 May;170(1):327-34 PMID: 15744049
  4. Rapid evolution of a coadapted gene complex: evidence from the Segregation Distorter (SD) system of meiotic drive in Drosophila melanogaster.
    Genetics. 1996 Aug;143(4):1675-88 PMID: 8844155
  5. Signature of selective sweep associated with the evolution of sex-ratio drive in Drosophila simulans.
    Genetics. 2004 Mar;166(3):1357-66 PMID: 15082554
  6. The effect of a selected locus on linked neutral loci.
    Genetics. 1977 Apr;85(4):753-88 PMID: 863244
  7. Genetic hitchhiking.
    Philos Trans R Soc Lond B Biol Sci. 2000 Nov 29;355(1403):1553-62 PMID: 11127900
  8. A novel meiotic drive locus almost completely distorts segregation in mimulus (monkeyflower) hybrids.
    Genetics. 2005 Jan;169(1):347-53 PMID: 15466426
  9. Centromeres: selfish drivers.
    Nature. 2002 May 16;417(6886):227 PMID: 12015578
  10. Population Dynamics of the Segregation Distorter Polymorphism of DROSOPHILA MELANOGASTER.
    Genetics. 1978 May;89(1):171-92 PMID: 17248828
  11. Meiotic Drive in Natural Populations of Drosophila Melanogaster. I. the Cytogenetic Basis of Segregation-Distortion.
    Genetics. 1959 Mar;44(2):233-50 PMID: 17247821
  12. Plant neocentromeres: fast, focused, and driven.
    Chromosome Res. 2004;12(6):655-69 PMID: 15289670
  13. Segregation distorters.
    Annu Rev Genet. 1991;25:511-57 PMID: 1812815
  14. Meiotic drive of chromosomal knobs reshaped the maize genome.
    Genetics. 1999 Sep;153(1):415-26 PMID: 10471723
  15. The hitch-hiking effect of a favourable gene.
    Genet Res. 1974 Feb;23(1):23-35 PMID: 4407212
  16. Segregation distortion in hybrids between the Bogota and USA subspecies of Drosophila pseudoobscura.
    Genetics. 2005 Feb;169(2):671-82 PMID: 15654115
  17. The role of selfish genetic elements in eukaryotic evolution.
    Nat Rev Genet. 2001 Aug;2(8):597-606 PMID: 11483984
  18. Conflict begets complexity: the evolution of centromeres.
    Curr Opin Genet Dev. 2002 Dec;12(6):711-8 PMID: 12433586
  19. Mouse t haplotypes.
    Annu Rev Genet. 1985;19:179-208 PMID: 3909941
  20. Female meiosis drives karyotypic evolution in mammals.
    Genetics. 2001 Nov;159(3):1179-89 PMID: 11729161
  21. Mimulus finds centromeres in the driver's seat.
    Trends Ecol Evol. 2005 Apr;20(4):151-4 PMID: 16701359
  22. Transmission ratio distortion in offspring of heterozygous female carriers of Robertsonian translocations.
    Hum Genet. 2001 Jan;108(1):31-6 PMID: 11214904
  23. Nonrandom segregation during meiosis: the unfairness of females.
    Mamm Genome. 2001 May;12(5):331-9 PMID: 11331939
  24. Common features of segregation distortion in plants and animals.
    Genetica. 2003 Jan;117(1):27-35 PMID: 12656570
Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1534/genetics.105.052977
Email
[email protected]
Published
2006-07-00
Epub
2006-00-19
Pages
1829-32
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1526655
Subset
IM
External Links
PubMed source DOI: 10.1534/genetics.105.052977 PMC Full Text View journal details
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