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PMID: 16624937 Published · ppublish English Comparative Study Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Two coincidence detectors for spike timing-dependent plasticity in somatosensory cortex.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 26 ·No. 16 ·2006-04-19 ·Pages 4166-77

Bender VA, Bender KJ, Brasier DJ, Feldman DE

Abstract

Many cortical synapses exhibit spike timing-dependent plasticity (STDP) in which the precise timing of presynaptic and postsynaptic spikes induces synaptic strengthening [long-term potentiation (LTP)] or weakening [long-term depression (LTD)]. Standard models posit a single, postsynaptic, NMDA receptor-based coincidence detector for LTP and LTD components of STDP. We show instead that STDP at layer 4 to layer 2/3 synapses in somatosensory (S1) cortex involves separate calcium sources and coincidence detection mechanisms for LTP and LTD. LTP showed classical NMDA receptor dependence. LTD was independent of postsynaptic NMDA receptors and instead required group I metabotropic glutamate receptors and calcium from voltage-sensitive channels and IP3 receptor-gated stores. Downstream of postsynaptic calcium, LTD required retrograde endocannabinoid signaling, leading to presynaptic LTD expression, and also required activation of apparently presynaptic NMDA receptors. These LTP and LTD mechanisms detected firing coincidence on approximately 25 and approximately 125 ms time scales, respectively, and combined to implement the overall STDP rule. These findings indicate that STDP is not a unitary process and suggest that endocannabinoid-dependent LTD may be relevant to cortical map plasticity.

MeSH Terms
Action Potentials/drug effects,physiology Animals Dizocilpine Maleate/pharmacology Neuronal Plasticity/drug effects,physiology Piperidines/pharmacology Pyrazoles/pharmacology Rats Rats, Long-Evans Receptors, N-Methyl-D-Aspartate/agonists,antagonists & inhibitors,physiology Somatosensory Cortex/drug effects,physiology Time Factors
Chemicals
Piperidines Pyrazoles Receptors, N-Methyl-D-Aspartate AM 251 Dizocilpine Maleate
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Bender Vanessa A
Neurosciences Program, University of California, San Diego, La Jolla, California 92093-0357, USA.
Bender Kevin J
Brasier Daniel J
Feldman Daniel E
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
1529-2401
DOI
10.1523/JNEUROSCI.0176-06.2006
Published
2006-04-19
Pages
4166-77
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC3071735
Subset
IM
Grants
NINDS NIH HHS · R01 NS046652 · United States
NINDS NIH HHS · R01 NS046652-05 · United States
External Links
PubMed source DOI: 10.1523/JNEUROSCI.0176-06.2006 PMC Full Text View journal details
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