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PMID: 16633488 Published · ppublish English Journal Article

Premorbid characterization in schizophrenia: the Pittsburgh High Risk Study.

World psychiatry : official journal of the World Psychiatric Association (WPA) ·Vol. 3 ·No. 3 ·2004-10-00 ·Pages 163-8

Keshavan MS, Diwadkar VA, Montrose DM, Stanley JA, Pettegrew JW

Abstract

Prospective studies of young relatives at risk for schizophrenia can shed light on the possible premorbid precursors of the disease. Ongoing studies in Pittsburgh suggest that young non-psychotic high risk relatives have neurobehavioral, brain structural, physiological, and neurochemical deficits that may date back to childhood or earlier. We summarize these data, review the relevant literature in this emerging field, and provide some new data suggesting alterations in sleep architecture in young relatives at risk for schizophrenia. Collectively, such data are likely to help us to predict the eventual emergence of schizophrenia, schizophrenia spectrum or non-spectrum psychopathology.

Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Keshavan Matcheri S
Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O'Hara Street, Pittsburgh, PA 15213, USA.
Diwadkar Vaibhav A
Montrose Debra M
Stanley Jeff A
Pettegrew Jay W
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Article Info
Journal
World psychiatry : official journal of the World Psychiatric Association (WPA)
Abbr.
World Psychiatry
ISSN
1723-8617
Published
2004-10-00
Pages
163-8
Language
English
Region
Italy
NLM ID
101189643
PMCID
PMC1414704
External Links
PubMed source PMC Full Text View journal details
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