Molecular recognition and targeting of lysosomal proteins.

Current opinion in cell biology ·Vol. 3 ·No. 4 ·1991-08-00 ·Pages 642-6

von Figura K

Abstract

Recent studies have established that in mammalian cells insulin-like growth factor-II can couple the large mannose-6-phosphate receptor to a GTP-binding protein and that the insulin-like growth factor-II-induced activation of the GTP-binding protein is inhibited by mannose-6-phosphate and lysosomal enzymes. In mouse, the gene for the large mannose-6-phosphate receptor is maternally imprinted.

Related Genes

MPR300 VPS15

MeSH Terms

Animals Coated Pits, Cell-Membrane/metabolism Embryonic and Fetal Development Enzymes/metabolism,pharmacology Fungal Proteins/metabolism GTP-Binding Proteins/metabolism Genes, Lethal Humans Insulin-Like Growth Factor II/antagonists & inhibitors,physiology Lysosomes/metabolism Mammals/metabolism Mannosephosphates/metabolism,pharmacology Membrane Proteins/metabolism Mice/embryology,genetics Mucolipidoses/metabolism Phosphorylation Phosphotransferases/metabolism Protein Binding Protein Kinases/metabolism Protein Processing, Post-Translational Receptor, IGF Type 2 Receptors, Cell Surface/genetics,metabolism Signal Transduction

Chemicals

Enzymes Fungal Proteins Mannosephosphates Membrane Proteins Receptor, IGF Type 2 Receptors, Cell Surface mannose-6-phosphate Insulin-Like Growth Factor II Phosphotransferases Protein Kinases GTP-Binding Proteins

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

von Figura K

Georg-August-Universitat, Göttingen, Germany.

Article Info

Journal

Current opinion in cell biology

Abbr.

Curr Opin Cell Biol

ISSN

0955-0674

DOI

10.1016/0955-0674(91)90035-w

Published

1991-08-00

Pages

642-6

Language

English

Region

England

NLM ID

8913428

Subset

External Links

PubMed source DOI: 10.1016/0955-0674(91)90035-w View journal details

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Molecular recognition and targeting of lysosomal proteins.

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