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PMID: 16636294 Published · ppublish English Comparative Study Journal Article

Short blocks from the noncoding parts of the human genome have instances within nearly all known genes and relate to biological processes.

Rigoutsos I, Huynh T, Miranda K, Tsirigos A, McHardy A, Platt D

Abstract

Using an unsupervised pattern-discovery method, we processed the human intergenic and intronic regions and catalogued all variable-length patterns with identically conserved copies and multiplicities above what is expected by chance. Among the millions of discovered patterns, we found a subset of 127,998 patterns, termed pyknons, which have additional nonoverlapping instances in the untranslated and protein-coding regions of 30,675 transcripts from 20,059 human genes. The pyknons arrange combinatorially in the untranslated and coding regions of numerous human genes where they form mosaics. Consecutive instances of pyknons in these regions show a strong bias in their relative placement, favoring distances of approximately 22 nucleotides. We also found pyknons to be enriched in a statistically significant manner in genes involved in specific processes, e.g., cell communication, transcription, regulation of transcription, signaling, transport, etc. For approximately 1/3 of the pyknons, the intergenic/intronic instances of their reverse complement lie within 380,084 nonoverlapping regions, typically 60-80 nucleotides long, which are predicted to form double-stranded, energetically stable, hairpin-shaped RNA secondary structures; additionally, the pyknons subsume approximately 40% of the known microRNA sequences, thus suggesting a possible link with posttranscriptional gene silencing and RNA interference. Cross-genome comparisons reveal that many of the pyknons have instances in the 3' UTRs of genes from other vertebrates and invertebrates where they are overrepresented in similar biological processes, as in the human genome. These unexpected findings suggest potential unique functional connections between the coding and noncoding parts of the human genome.

MeSH Terms
3' Untranslated Regions 5' Untranslated Regions Animals Base Sequence Conserved Sequence DNA/genetics Genome, Human Humans Introns Molecular Sequence Data Open Reading Frames RNA Interference Untranslated Regions
Chemicals
3' Untranslated Regions 5' Untranslated Regions Untranslated Regions DNA
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Rigoutsos Isidore
IBM Thomas J. Watson Research Center, P.O. Box 218, Yorktown Heights, NY 10598, USA. [email protected]
Huynh Tien
Miranda Kevin
Tsirigos Aristotelis
McHardy Alice
Platt Daniel
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
Published
2006-04-25
Epub
2006-00-24
Pages
6605-10
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC1447521
Subset
IM
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