Sister chromatid cohesion at the centromere: confrontation between kinases and phosphatases?

Developmental cell ·Vol. 10 ·No. 5 ·2006-05-00 ·Pages 544-7

Clarke A, Orr-Weaver TL

Abstract

Accurate chromosome segregation in mitosis and meiosis requires that the cohesin complex be protected at the centromere by the Shugoshin/MEI-S332 protein family. Recent studies show that Sgo directly binds the phosphatase PP2A, tethering it to the centromere where it can protect cohesin subunits from phosphorylation, and that localization of Sgo/MEI-S332 itself is regulated by phosphorylation.

MeSH Terms

Animals Cell Cycle Proteins/metabolism Centromere/enzymology,metabolism Chromatids/enzymology,metabolism Chromosomal Proteins, Non-Histone/metabolism Drosophila/genetics Gene Expression Regulation, Enzymologic Humans Nuclear Proteins/metabolism Phosphoric Monoester Hydrolases/metabolism Phosphotransferases/metabolism

Chemicals

Cell Cycle Proteins Chromosomal Proteins, Non-Histone Nuclear Proteins cohesins Phosphotransferases Phosphoric Monoester Hydrolases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Clarke Astrid

Whitehead Institute and Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA.

Orr-Weaver Terry L

Article Info

Journal

Developmental cell

Abbr.

Dev Cell

ISSN

1534-5807

DOI

10.1016/j.devcel.2006.04.017

Published

2006-05-00

Pages

544-7

Language

English

Region

United States

NLM ID

101120028

Subset

Corrections

CommentOn

PMID: 16580887

External Links

PubMed source DOI: 10.1016/j.devcel.2006.04.017 View journal details

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Sister chromatid cohesion at the centromere: confrontation between kinases and phosphatases?

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