Variation of proliferative activity in leukemic cell populations of patients with acute leukemia.

The Journal of clinical investigation ·Vol. 46 ·No. 8 ·1967-08-00 ·Pages 1356-63

Saunders EF, Lampkin BC, Mauer AM

Abstract

In 31 children with acute leukemia, the proliferative activity of the leukemic marrow cell population as measured by mitotic and labeling indexes varied widely from patient to patient and from one disease stage to another. Leukemic marrow had a small but statistically significant diurnal variation of proliferative activity. Changes in labeling indexes were directly related to changes in the proportion of large dividing blasts in the marrow. Generation times of dividing leukemic blast cells in 3 patients were similar at diagnosis and in relapse. Changes in proliferative activity of leukemic marrow can be explained by progressive accumulation of nondividing leukemic cells.

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Saunders E F

Department of Pediatrics, University of Cincinnati, The Children's Hospital, and The Children's Hospital Research Foundation, Cincinnati, Ohio.

Lampkin B C

Mauer A M

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13 references, click to expand

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Article Info

Journal

The Journal of clinical investigation

Abbr.

J Clin Invest

ISSN

0021-9738

DOI

10.1172/JCI105628

Published

1967-08-00

Pages

1356-63

Language

English

Region

United States

NLM ID

7802877

PMCID

PMC297137

External Links

PubMed source DOI: 10.1172/JCI105628 PMC Full Text View journal details

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Variation of proliferative activity in leukemic cell populations of patients with acute leukemia.

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