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PMID: 16709637 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

The role of AMP-activated protein kinase in mitochondrial biogenesis.

The Journal of physiology ·Vol. 574 ·No. Pt 1 ·2006-07-01 ·Pages 33-9

Reznick RM, Shulman GI

Abstract

While it has been known for more than 75 years that physical activity is associated with increased mitochondrial content in muscle, the molecular mechanism for this adaptive process has only recently been elucidated. This brief review examines existing studies that have identified AMPK-activated protein kinase (AMPK) and several other key regulators of mitochondrial biogenesis, including peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta, calcium/calmodulin-dependent protein kinase IV, and nitric oxide. In addition, the potential role of mitochondrial dysfunction in the pathogenesis of insulin resistance associated with ageing and type 2 diabetes mellitus is also discussed.

MeSH Terms
AMP-Activated Protein Kinases Animals Diabetes Mellitus, Type 2/enzymology Energy Metabolism/physiology Exercise/physiology Humans Mitochondria, Muscle/physiology Mitochondrial Proteins/metabolism Multienzyme Complexes/metabolism Muscle Contraction/physiology Muscle, Skeletal/physiology Physical Endurance/physiology Physical Exertion/physiology Protein Serine-Threonine Kinases/metabolism
Chemicals
Mitochondrial Proteins Multienzyme Complexes Protein Serine-Threonine Kinases AMP-Activated Protein Kinases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Reznick Richard M
Department of Inernal Medicine,Yale University School of Medicine, Howard Hughes Medical Institute, New Haven, CT, USA.
Shulman Gerald I
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.2006.109512
Published
2006-07-01
Epub
2006-00-18
Pages
33-9
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1817787
Subset
IM
Grants
NIDDK NIH HHS · R01 DK-40936 · United States
NIDDK NIH HHS · U24 DK-59635 · United States
NIDDK NIH HHS · U24 DK059635 · United States
NIDDK NIH HHS · P01 DK-068229 · United States
NIDDK NIH HHS · P01 DK068229 · United States
NIDDK NIH HHS · P30 DK-45735 · United States
NIDDK NIH HHS · R01 DK040936 · United States
NIDDK NIH HHS · P30 DK045735 · United States
PHS HHS · T32G-07499 · United States
External Links
PubMed source DOI: 10.1113/jphysiol.2006.109512 PMC Full Text View journal details
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