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PMID: 16714479 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Astrocytes coordinate synaptic networks: balanced excitation and inhibition.

Physiology (Bethesda, Md.) ·Vol. 21 ·2006-06-00 ·Pages 208-15

Fellin T, Pascual O, Haydon PG

Abstract

Although neurons are essential for brain function, an emerging alternative view holds that astrocytes, the dominant glial cell type, coordinate synaptic networks. Through the release of glutamate, astrocytes locally excite neurons, and via adenosine, which accumulates due to the hydrolysis of released ATP, astrocytes suppress distant synapses.

MeSH Terms
Adenosine/metabolism Adenosine Triphosphate/metabolism Animals Astrocytes/physiology Glutamic Acid/metabolism Humans Synapses/physiology Synaptic Transmission/physiology
Chemicals
Glutamic Acid Adenosine Triphosphate Adenosine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Fellin Tommaso
Department of Neuroscience, Silvio Conte Center for Integration at the Tripartite Synapse, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Pascual Olivier
Haydon Philip G
Article Info
Journal
Physiology (Bethesda, Md.)
Abbr.
Physiology (Bethesda)
ISSN
1548-9213
DOI
10.1152/physiol.00161.2005
Published
2006-06-00
Pages
208-15
Language
English
Region
United States
NLM ID
101208185
Subset
IM
External Links
PubMed source DOI: 10.1152/physiol.00161.2005 View journal details
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