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PMID: 1671667 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Haplotypic polymorphisms of the TNFB gene.

Immunogenetics ·Vol. 33 ·No. 1 ·1991-00-00 ·Pages 50-3

Abraham LJ, Du DC, Zahedi K, Dawkins RL, Whitehead AS

Abstract

The TNFB genes from two major histocompatibility complex (MHC) ancestral haplotypes have been compared. The genes carried by the ancestral haplotypes 8.1 (A1,B8,BfS,C4AQ0, C4B1,DR3) and 57.1 (A1, B57. BfS, C4A6, C4B1, DR7) were cloned and sequenced to determine the degree of polymorphism. In this report we show that the respective TNF genes are allelic and have unique nucleotide sequences. The data demonstrate the presence of three nucleotide differences between the TNFB alleles of 8.1 and 57.1. Two of the differences occur in untranslated regions of the gene but the third nucleotide change results in an amino acid difference in the mature TNFB protein. These polymorphisms may have implications with respect to differential regulation in disease- and nondisease-associated haplotypes.

Related Genes
TNFB
MeSH Terms
Alleles Base Sequence Cloning, Molecular Gene Library Haplotypes Humans Lymphotoxin-alpha/genetics Major Histocompatibility Complex/genetics Molecular Sequence Data Polymorphism, Restriction Fragment Length Sequence Homology, Nucleic Acid Tumor Necrosis Factor-alpha/genetics
Chemicals
Lymphotoxin-alpha Tumor Necrosis Factor-alpha
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Abraham L J
Department of Clinical Immunology, Royal Perth Hospital, Western Australia.
Du D C
Zahedi K
Dawkins R L
Whitehead A S
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Article Info
Journal
Immunogenetics
Abbr.
Immunogenetics
ISSN
0093-7711
DOI
10.1007/BF00211695
Published
1991-00-00
Pages
50-3
Language
English
Region
United States
NLM ID
0420404
Subset
IM
Databases
GENBANK
M55913, M74709, M76774, M76775, M76776, M76777, M76778, M76779, M76780, S40906
External Links
PubMed source DOI: 10.1007/BF00211695 View journal details
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