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PMID: 16742434 Published · ppublish English Journal Article

Turnover of brain mitochondrial membrane lipids.

The Biochemical journal ·Vol. 101 ·No. 3 ·1966-12-00 ·Pages 618-26

Cuzner ML, Davison AN, Gregson NA

Abstract

1. The turnover of lipids, of myelin and other brain subcellular particles has been studied in double-labelling experiments on intact rats. 2. Overall metabolism of brain mitochondrial lipids was three times slower than that of the liver. 3. Individual lipids of brain mitochondria and myelin were also separated and their metabolism was studied. 4. All myelin lipids examined undergo very slow turnover. Two pools of brain mitochondrial lipid were identified. The slowly metabolized lipids were cholesterol, cardiolipin plus phosphatidic acid and possibly sphingomyelin; the remaining phosphatides underwent more rapid turnover. 5. The possible significance of these results is discussed.

Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Cuzner M L
Department of Biochemistry, Charing Cross Hospital Medical School, London, W.C. 2.
Davison A N
Gregson N A
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1010618
Published
1966-12-00
Pages
618-26
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1270162
External Links
PubMed source DOI: 10.1042/bj1010618 PMC Full Text View journal details
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