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PMID: 16749121 Published · ppublish English Journal Article

Depletion of glycogen synthetase and increase of glucose 6-phosphate dehydrogenase in livers of ethionine-treated mice.

The Biochemical journal ·Vol. 97 ·No. 1 ·1965-10-00 ·Pages 32-6

Sie HG, Hablanian A

Abstract

1. Ethionine-treated mice showed a marked depletion in liver glycogen, a decrease of glycogen-synthetase activity, an increase in activity of glucose 6-phosphate dehydrogenase and the solubilization of phosphorylase. 2. The administration of cortisol or glucose did not alleviate these changes but the effect of ethionine was completely prevented in animals given methionine as well as ethionine. 3. The activities of the following enzymes were unchanged: hexokinase, glucokinase, glucose 6-phosphatase, phosphoglucomutase, 6-phosphogluconate dehydrogenase, UDP-glucose pyrophosphorylase, UDP-glucose dehydrogenase and pyruvate kinase.

Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sie H G
Tufts University School of Medicine and the Cancer Research Department, New England Center Hospital, Boston, Mass., U.S.A.
Hablanian A
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22 references, click to expand
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Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj0970032
Published
1965-10-00
Pages
32-6
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1264540
External Links
PubMed source DOI: 10.1042/bj0970032 PMC Full Text View journal details
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