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PMID: 16753553 Published · ppublish English Comment Journal Article

Checkpoint activation: don't get mad too much.

Current biology : CB ·Vol. 16 ·No. 11 ·2006-06-06 ·Pages R412-4

Lénárt P, Peters JM

Abstract

The Mad2 protein is required to delay sister chromatid separation until all chromosomes have been aligned on the mitotic spindle. Two recent studies provide new insights into how Mad2 contributes to this remarkable task.

MeSH Terms
Calcium-Binding Proteins/physiology Cell Cycle/physiology Cell Cycle Proteins/physiology Chromatids/metabolism Genes, cdc Humans Kinetochores/metabolism Mad2 Proteins Repressor Proteins/physiology Spindle Apparatus/metabolism
Chemicals
Calcium-Binding Proteins Cell Cycle Proteins MAD2L1 protein, human Mad2 Proteins Repressor Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Lénárt Péter
Research Institute of Molecular Pathology (IMP), Dr. Bohr-Gasse 7, A-1030 Vienna, Austria. [email protected]
Peters Jan-Michael
Article Info
Journal
Current biology : CB
Abbr.
Curr Biol
ISSN
0960-9822
DOI
10.1016/j.cub.2006.05.008
Email
[email protected]
Published
2006-06-06
Pages
R412-4
Language
English
Region
England
NLM ID
9107782
Subset
IM
Corrections
CommentOn
PMID: 16631582
External Links
PubMed source DOI: 10.1016/j.cub.2006.05.008 View journal details
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