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PMID: 16759408 Published · epublish English Journal Article

The spindle position checkpoint in budding yeast: the motherly care of MEN.

Cell division ·Vol. 1 ·No. 1 ·2006-04-03 ·Pages 2

Piatti S, Venturetti M, Chiroli E, Fraschini R

Abstract

Mitotic exit and cytokinesis must be tightly coupled to nuclear division both in time and space in order to preserve genome stability and to ensure that daughter cells inherit the right set of chromosomes after cell division. This is achieved in budding yeast through control over a signal transduction cascade, the mitotic exit network (MEN), which is required for mitotic CDK inactivation in telophase and for cytokinesis. Current models of MEN activation emphasize on the bud as the place where most control is exerted. This review focuses on recent data that instead point to the mother cell as being the residence of key regulators of late mitotic events.

Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Piatti Simonetta
Dipartimento di Biotecnologie e Bioscienze, Universita' di Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy. [email protected].
Venturetti Marianna
Chiroli Elena
Fraschini Roberta
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Article Info
Journal
Cell division
Abbr.
Cell Div
ISSN
1747-1028
DOI
10.1186/1747-1028-1-2
Email
[email protected]
Published
2006-04-03
Epub
2006-00-03
Pages
2
Language
English
Region
England
NLM ID
101251560
PMCID
PMC1459270
Grants
Telethon · GGP05034 · Italy
External Links
PubMed source DOI: 10.1186/1747-1028-1-2 PMC Full Text View journal details
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