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PMID: 16770732 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Immediate and delayed treatments with curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus.

Neurochemical research ·Vol. 31 ·No. 5 ·2006-05-00 ·Pages 611-8

Al-Omar FA, Nagi MN, Abdulgadir MM, Al Joni KS, Al-Majed AA

Abstract

Oxidative stress is believed to contribute to neurodegeneration following ischemic injury. The present study was undertaken to evaluate the possible antioxidant neuroprotective effect of curcumin (Cur) on neuronal death of hippocampal CA1 neurons following transient forebrain ischemia in rat. Treatment of Cur (200 mg/kg/day, i.p.) at three different times (immediately, 3 h and 24 h after ischemia) significantly (P<0.01) reduced neuronal damage 7 days after ischemia. Also, treatment of ischemic rats with Cur decreased the elevated levels of MDA and increased GSH contents, catalase and SOD activities to normal levels. In the in vitro, Cur was as potent as antioxidant (IC(50) = 1 microM) as butylated hydroxytoluene. The present study demonstrates that curcumin treatment attenuates forebrain ischemia-induced neuronal injury and oxidative stress in hippocampal tissue. Thus treatment with curcumin immediately or even delayed until 24 h may have the potential to be used as a protective agent in forebrain ischemic insult in human.

MeSH Terms
Animals Antioxidants/metabolism Apoptosis Brain Ischemia/pathology Catalase/metabolism Curcumin/metabolism,therapeutic use Enzyme Inhibitors/metabolism,therapeutic use Glutathione/metabolism Hippocampus/cytology,metabolism,pathology Humans Iron/metabolism Lipid Peroxidation Male Malondialdehyde/metabolism Neurons/cytology,metabolism,pathology Neuroprotective Agents/metabolism,therapeutic use Oxidative Stress Prosencephalon/metabolism,pathology Rats Rats, Wistar Superoxide Dismutase/metabolism
Chemicals
Antioxidants Enzyme Inhibitors Neuroprotective Agents Malondialdehyde Iron Catalase Superoxide Dismutase Glutathione Curcumin
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Al-Omar Fadhel A
Department of Pharmacology, College of Pharmacy, King Saud University, P.O. Box 2457, 11451 Riyadh, Kingdom of Saudi Arabia.
Nagi Mahmoud N
Abdulgadir Mustafa M
Al Joni Khalda S
Al-Majed Abdulhakeem A
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Article Info
Journal
Neurochemical research
Abbr.
Neurochem Res
ISSN
0364-3190
DOI
10.1007/s11064-006-9059-1
Published
2006-05-00
Epub
2006-00-23
Pages
611-8
Language
English
Region
United States
NLM ID
7613461
Subset
IM
External Links
PubMed source DOI: 10.1007/s11064-006-9059-1 View journal details
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