Expression of the envelope antigen F1 of Yersinia pestis is mediated by the product of caf1M gene having homology with the chaperone protein PapD of Escherichia coli.

FEBS letters ·Vol. 286 ·No. 1-2 ·1991-07-29 ·Pages 79-82

Galyov EE, Karlishev AV, Chernovskaya TV, Dolgikh DA, Smirnov OYu, Volkovoy KI, Abramov VM, Zav'yalov VP

Abstract

The effective synthesis of the envelope antigen F1 of Y. pestis in E. coli HB101 is mediated by the expression of the caf1M gene. This gene was sequenced, and the protein encoded was found to have a significant homology with the chaperone protein PapD of uropathogenic E. coli. The data presented allow one to suppose Caf1M and PapD proteins perform similar functions in the biogenesis of the Y. pestis capsule and E. coli P-pili, respectively.

MeSH Terms

Adhesins, Escherichia coli Amino Acid Sequence Antigens, Bacterial/genetics,metabolism Bacterial Outer Membrane Proteins/genetics Bacterial Proteins/genetics,metabolism Base Sequence DNA, Bacterial Escherichia coli/genetics Gene Expression Genes, Bacterial Molecular Chaperones Molecular Sequence Data Restriction Mapping Sequence Homology, Nucleic Acid Yersinia pestis/genetics,immunology

Chemicals

Adhesins, Escherichia coli Antigens, Bacterial Bacterial Outer Membrane Proteins Bacterial Proteins DNA, Bacterial Molecular Chaperones CAf1M protein, Yersinia pestis

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Galyov E E

Institute of Immunology, Lyubuchany, Moscow Region, USSR.

Karlishev A V

Chernovskaya T V

Dolgikh D A

Smirnov OYu

Volkovoy K I

Abramov V M

Zav'yalov V P

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(91)80945-y

Published

1991-07-29

Pages

79-82

Language

English

Region

England

NLM ID

0155157

Subset

Databases

GENBANK

M95211, X58797, X58798, X58799, X58800, X58801, X58802, X58803, X61996, X62841

External Links

PubMed source DOI: 10.1016/0014-5793(91)80945-y View journal details

Analysis Services

Expression of the envelope antigen F1 of Yersinia pestis is mediated by the product of caf1M gene having homology with the chaperone protein PapD of Escherichia coli.

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