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PMID: 16785318 Published · ppublish English Comment Journal Article Research Support, Non-U.S. Gov't

"HURP on" we're off to the kinetochore!

The Journal of cell biology ·Vol. 173 ·No. 6 ·2006-06-19 ·Pages 829-31

Wilde A

Abstract

RanGTP has a central role in spindle assembly, but the Ran-regulated factors required to initiate spindle bipolarity and stabilize MT growth toward the chromosomes remain unknown. However, three recent papers (Koffa et al., 2006; Sillje et al., 2006; Wong and Fang, 2006) have identified a single factor, HURP, that may encompass both of these properties.

MeSH Terms
Animals Cell Cycle Proteins/metabolism,physiology Cell Nucleus Division/genetics,physiology HeLa Cells Humans Kinetochores/metabolism Microtubule-Associated Proteins/metabolism Microtubules/metabolism Models, Biological Neoplasm Proteins/physiology Spindle Apparatus Xenopus ran GTP-Binding Protein/physiology
Chemicals
Cell Cycle Proteins DLGAP5 protein, human Microtubule-Associated Proteins Neoplasm Proteins ran GTP-Binding Protein
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Wilde Andrew
Department of Medical Genetics and Microbiology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.
References (16)
16 references, click to expand
  1. Ran stimulates spindle assembly by altering microtubule dynamics and the balance of motor activities.
    Nat Cell Biol. 2001 Mar;3(3):221-7 PMID: 11231570
  2. HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture.
    J Cell Biol. 2006 Jun 19;173(6):879-91 PMID: 16769820
  3. The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly.
    Nat Cell Biol. 2002 Jul;4(7):E177-84 PMID: 12105431
  4. A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly.
    Nat Cell Biol. 2003 Mar;5(3):242-8 PMID: 12577065
  5. Importin alpha-regulated nucleation of microtubules by TPX2.
    EMBO J. 2003 May 1;22(9):2060-70 PMID: 12727873
  6. Ran modulates spindle assembly by regulating a subset of TPX2 and Kid activities including Aurora A activation.
    J Cell Sci. 2003 Dec 1;116(Pt 23):4791-8 PMID: 14600264
  7. Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells.
    Genes Dev. 2004 Mar 1;18(5):512-27 PMID: 15014043
  8. Mechanisms and molecules of the mitotic spindle.
    Curr Biol. 2004 Sep 21;14(18):R797-805 PMID: 15380094
  9. Efficient chromosome capture requires a bias in the 'search-and-capture' process during mitotic-spindle assembly.
    Curr Biol. 2005 May 10;15(9):828-32 PMID: 15886100
  10. Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A.
    Mol Cell Biol. 2005 Jul;25(14):5789-800 PMID: 15987997
  11. Spatial coordination of spindle assembly by chromosome-mediated signaling gradients.
    Science. 2005 Aug 26;309(5739):1373-6 PMID: 16123300
  12. Molecular requirements for kinetochore-associated microtubule formation in mammalian cells.
    Curr Biol. 2006 Mar 7;16(5):536-41 PMID: 16527751
  13. Ran is required before metaphase for spindle assembly and chromosome alignment and after metaphase for chromosome segregation and spindle midbody organization.
    Mol Biol Cell. 2006 Apr;17(4):2069-80 PMID: 16481399
  14. Analysis of a RanGTP-regulated gradient in mitotic somatic cells.
    Nature. 2006 Mar 30;440(7084):697-701 PMID: 16572176
  15. HURP is a Ran-importin beta-regulated protein that stabilizes kinetochore microtubules in the vicinity of chromosomes.
    Curr Biol. 2006 Apr 18;16(8):731-42 PMID: 16631580
  16. HURP is part of a Ran-dependent complex involved in spindle formation.
    Curr Biol. 2006 Apr 18;16(8):743-54 PMID: 16631581
Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.200605150
Published
2006-06-19
Pages
829-31
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2063907
Subset
IM
Corrections
CommentOn
PMID: 16769820
External Links
PubMed source DOI: 10.1083/jcb.200605150 PMC Full Text View journal details
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