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PMID: 1678612 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Isolation and characterization of a novel cDNA clone encoding a homeodomain that is developmentally regulated in the ventral forebrain.

Neuron ·Vol. 7 ·No. 2 ·1991-08-00 ·Pages 221-9

Porteus MH, Bulfone A, Ciaranello RD, Rubenstein JL

Abstract

A complementary DNA, Tes-1, of a novel homeodomain protein has been cloned, and its pattern of expression has been characterized. It is a structural homolog of Distal-less, a homeodomain-encoding gene in D. melanogaster. Its expression is developmentally regulated and is limited to structures in the head. Within the central nervous system of the midgestation mouse embryo, it is expressed exclusively in the ventral forebrain. It is likely that Tes-1 plays a regulatory role in the development of this complex neural structure.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Brain/embryology,metabolism,physiology Cloning, Molecular DNA/genetics,isolation & purification,metabolism Female Genes, Homeobox/genetics Mice Mice, Inbred BALB C Molecular Sequence Data Pregnancy RNA, Messenger/genetics,metabolism Transcription, Genetic/genetics
Chemicals
RNA, Messenger DNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Porteus M H
Department of Psychiatry and Behavioral Sciences, Stanford Medical School, Stanford University, California 94305.
Bulfone A
Ciaranello R D
Rubenstein J L
Article Info
Journal
Neuron
Abbr.
Neuron
ISSN
0896-6273
DOI
10.1016/0896-6273(91)90260-7
Published
1991-08-00
Pages
221-9
Language
English
Region
United States
NLM ID
8809320
Subset
IM
Databases
GENBANK
M80540, S61932, S61935, S70258, S70261, S70262, X57453, X57454, X57455, X63253
Corrections
ErratumIn
PMID: 1632970
External Links
PubMed source DOI: 10.1016/0896-6273(91)90260-7 View journal details
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