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PMID: 167878 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Iontophoresis of cyclic AMP.

Biophysical journal ·Vol. 15 ·No. 8 ·1975-08-00 ·Pages 753-63

Cohen MH, Drage DJ, Robertson A

Abstract

The design, calibration, and operation of a source of controlled amounts of cyclic AMP (c-AMP) are described. Typically, 1.5 s pulses containing 10(10)-10(-12) molecules of c-AMP can be delivered to a region about 10 mum in diameter on an agar plate. The resulting concentration profiles are given as functions of distance and time. The diffusion coefficient of c-AMP in agar was measured to be 0.97 times 10(-5) cm2-s-1 at 21 degrees C.

MeSH Terms
Agar Cyclic AMP Dictyostelium/metabolism Diffusion Electrochemistry Iontophoresis/instrumentation Microelectrodes
Chemicals
Agar Cyclic AMP
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Cohen M H
Drage D J
Robertson A
References (7)
7 references, click to expand
  1. Stimulation of late interphase Dictyostelium discoideum amoebae with an external cyclic AMP signal.
    Biophys J. 1975 Aug;15(8):765-75 PMID: 167879
  2. Wave propagation in the early stages of aggregation of cellular slime molds.
    J Theor Biol. 1971 Apr;31(1):101-18 PMID: 4325172
  3. Chemotaxis and the early stages of aggregation in cellular slime molds.
    J Theor Biol. 1971 Apr;31(1):119-30 PMID: 4325173
  4. Control of developing fields.
    Annu Rev Biophys Bioeng. 1972;1:409-64 PMID: 4405416
  5. Epigenetic development in the cellular slime moulds.
    Symp Soc Exp Biol. 1963;17:341-58 PMID: 5850874
  6. Cell aggregation and differentiation in Dictyostelium.
    Curr Top Dev Biol. 1968;3:157-97 PMID: 5002049
  7. Control of Aggregation in Dictyostelium discoideum by an External Periodic Pulse of Cyclic Adenosine Monophosphate.
    Science. 1972 Jan 21;175(4019):333-5 PMID: 17814544
Article Info
Journal
Biophysical journal
Abbr.
Biophys J
ISSN
0006-3495
DOI
10.1016/S0006-3495(75)85852-8
Published
1975-08-00
Pages
753-63
Language
English
Region
United States
NLM ID
0370626
PMCID
PMC1334778
Subset
IM
External Links
PubMed source DOI: 10.1016/S0006-3495(75)85852-8 PMC Full Text View journal details
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