Home LiteratureArticle Details
PMID: 16792804 Published · epublish English Journal Article

Disjunction of conjoined twins: Cdk1, Cdh1 and separation of centrosomes.

Cell division ·Vol. 1 ·2006-06-22 ·Pages 12

Crasta K, Surana U

Abstract

Accurate transmission of chromosomes from parent to progeny cell requires assembly of a bipolar spindle. Centrosomes (spindle pole body in yeast) are critical for the biogenesis of this complex mitotic apparatus since they confer bipolarity on the spindle and serve as the site of microtubule polymerization. In each division cycle, the centrosome is duplicated and the sister-centrosomes move away from each other, forming the two poles of the spindle. While the structure and the duplication of centrosomes have been investigated extensively, the understanding of the control of their segregation remains scant. Recent findings are beginning to yield insights into the regulation of centrosome segregation in yeast and its link to the mitotic kinase.

Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Crasta Karen
Institute of Molecular and Cell Biology, Proteos, 61 Biopolis Drive, 138673, Singapore. [email protected]
Surana Uttam
References (40)
40 references, click to expand
  1. Replication of basal bodies and centrioles.
    Curr Opin Cell Biol. 1992 Feb;4(1):80-5 PMID: 1558756
  2. A molecular marker for centriole maturation in the mammalian cell cycle.
    J Cell Biol. 1995 Aug;130(4):919-27 PMID: 7642707
  3. Mechanistic analysis of the mitotic kinesin Eg5.
    J Biol Chem. 2004 Sep 10;279(37):38861-70 PMID: 15247293
  4. The bimC family of kinesins: essential bipolar mitotic motors driving centrosome separation.
    Biochim Biophys Acta. 1997 Jul 24;1357(3):257-71 PMID: 9268050
  5. Localization of core spindle pole body (SPB) components during SPB duplication in Saccharomyces cerevisiae.
    J Cell Biol. 1999 May 17;145(4):809-23 PMID: 10330408
  6. Cdk1 regulates centrosome separation by restraining proteolysis of microtubule-associated proteins.
    EMBO J. 2006 Jun 7;25(11):2551-63 PMID: 16688214
  7. The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1.
    Genes Dev. 2000 Mar 15;14(6):655-65 PMID: 10733526
  8. polo, a mitotic mutant of Drosophila displaying abnormal spindle poles.
    J Cell Sci. 1988 Jan;89 ( Pt 1):25-38 PMID: 3417791
  9. Re-evaluating centrosome function.
    Nat Rev Mol Cell Biol. 2001 Sep;2(9):688-98 PMID: 11533726
  10. Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes.
    J Cell Biol. 1996 Dec;135(6 Pt 2):1701-13 PMID: 8991084
  11. Characterization of four B-type cyclin genes of the budding yeast Saccharomyces cerevisiae.
    Mol Biol Cell. 1992 Jul;3(7):805-18 PMID: 1387566
  12. Spindle pole centrosomes of sea urchin embryos are partially composed of material recruited from maternal stores.
    Dev Biol. 1991 Oct;147(2):343-53 PMID: 1916013
  13. Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen.
    Science. 1999 Oct 29;286(5441):971-4 PMID: 10542155
  14. Centrosome-associated RNA in surf clam oocytes.
    Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9034-8 PMID: 16754862
  15. The bipolar mitotic kinesin Eg5 moves on both microtubules that it crosslinks.
    Nature. 2005 May 5;435(7038):114-8 PMID: 15875026
  16. Rootletin forms centriole-associated filaments and functions in centrosome cohesion.
    J Cell Biol. 2005 Oct 10;171(1):27-33 PMID: 16203858
  17. The paternal inheritance of the centrosome, the cell's microtubule-organizing center, in humans, and the implications for infertility.
    Nat Med. 1995 Jan;1(1):47-52 PMID: 7584952
  18. The rate of bipolar spindle assembly depends on the microtubule-gliding velocity of the mitotic kinesin Eg5.
    Curr Biol. 2004 Oct 5;14(19):1783-8 PMID: 15458652
  19. Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles.
    Cell. 1995 Apr 7;81(1):95-105 PMID: 7720077
  20. Motile properties of the kinesin-related Cin8p spindle motor extracted from Saccharomyces cerevisiae cells.
    J Biol Chem. 1999 Apr 2;274(14):9564-72 PMID: 10092642
  21. Role of the centrosome in organizing the interphase microtubule array: properties of cytoplasts containing or lacking centrosomes.
    J Cell Biol. 1984 May;98(5):1763-76 PMID: 6725398
  22. Spindle pole body separation in Saccharomyces cerevisiae requires dephosphorylation of the tyrosine 19 residue of Cdc28.
    Mol Cell Biol. 1996 Nov;16(11):6385-97 PMID: 8887667
  23. "It takes two to tango": understanding how centrosome duplication is regulated throughout the cell cycle.
    Genes Dev. 2001 May 15;15(10):1167-81 PMID: 11358861
  24. Nonperiodic activity of the human anaphase-promoting complex-Cdh1 ubiquitin ligase results in continuous DNA synthesis uncoupled from mitosis.
    Mol Cell Biol. 2000 Oct;20(20):7613-23 PMID: 11003657
  25. The Xenopus laevis aurora-related protein kinase pEg2 associates with and phosphorylates the kinesin-related protein XlEg5.
    J Biol Chem. 1999 May 21;274(21):15005-13 PMID: 10329703
  26. Kinesin-related proteins required for assembly of the mitotic spindle.
    J Cell Biol. 1992 Jul;118(1):95-108 PMID: 1618910
  27. CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation.
    J Cell Sci. 2002 May 1;115(Pt 9):1825-35 PMID: 11956314
  28. Epsilon-tubulin is required for centriole duplication and microtubule organization.
    Nat Cell Biol. 2003 Jan;5(1):71-6 PMID: 12510196
  29. Mitotic spindle function in Saccharomyces cerevisiae requires a balance between different types of kinesin-related motors.
    Mol Biol Cell. 1997 Jun;8(6):1025-33 PMID: 9201713
  30. Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo.
    Cell. 1995 Dec 29;83(7):1159-69 PMID: 8548803
  31. A chemical switch for inhibitor-sensitive alleles of any protein kinase.
    Nature. 2000 Sep 21;407(6802):395-401 PMID: 11014197
  32. The budding yeast spindle pole body: structure, duplication, and function.
    Annu Rev Cell Dev Biol. 2004;20:1-28 PMID: 15473833
  33. Centrosomes in cellular regulation.
    Annu Rev Cell Dev Biol. 2005;21:411-34 PMID: 16212501
  34. The yeast spindle pole body is assembled around a central crystal of Spc42p.
    Cell. 1997 Jun 27;89(7):1077-86 PMID: 9215630
  35. Centriole cycle in Chinese hamster ovary cells as determined by whole-mount electron microscopy.
    J Cell Biol. 1981 Dec;91(3 Pt 1):814-21 PMID: 7328123
  36. Spindle pole body duplication: a model for centrosome duplication?
    Trends Cell Biol. 2000 Aug;10(8):329-35 PMID: 10884685
  37. Nek2A kinase stimulates centrosome disjunction and is required for formation of bipolar mitotic spindles.
    Mol Biol Cell. 2003 Jul;14(7):2876-89 PMID: 12857871
  38. Two Saccharomyces cerevisiae kinesin-related gene products required for mitotic spindle assembly.
    J Cell Biol. 1992 Jul;118(1):109-20 PMID: 1618897
  39. The Nek2 protein kinase: a novel regulator of centrosome structure.
    Oncogene. 2002 Sep 9;21(40):6184-94 PMID: 12214248
  40. Structural role of Sfi1p-centrin filaments in budding yeast spindle pole body duplication.
    J Cell Biol. 2006 Jun 19;173(6):867-77 PMID: 16785321
Article Info
Journal
Cell division
Abbr.
Cell Div
ISSN
1747-1028
DOI
10.1186/1747-1028-1-12
Email
[email protected]
Published
2006-06-22
Epub
2006-00-22
Pages
12
Language
English
Region
England
NLM ID
101251560
PMCID
PMC1550386
External Links
PubMed source DOI: 10.1186/1747-1028-1-12 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2