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PMID: 16816134 Published · ppublish English Journal Article Research Support, N.I.H., Extramural Review

Retinoblastoma tumor suppressor: where cancer meets the cell cycle.

Experimental biology and medicine (Maywood, N.J.) ·Vol. 231 ·No. 7 ·2006-07-00 ·Pages 1271-81

Knudsen ES, Knudsen KE

Abstract

The retinoblastoma tumor suppressor gene, Rb, was the first tumor suppressor identified and plays a fundamental role in regulation of progression through the cell cycle. This review details facets of RB protein function in cell cycle control and focuses on specific questions that remain intensive areas of investigation.

MeSH Terms

Cell Cycle/genetics Eye Neoplasms/genetics,pathology Gene Expression Regulation, Neoplastic Genes, Retinoblastoma Homeostasis Humans Retinoblastoma/genetics,pathology

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Knudsen Erik S

Department of Cell Biology and University of Cincinnati Cancer Center, University of Cincinnati, Cincinnati, Ohio 45267-0521, USA. [email protected]

Knudsen Karen E

Article Info

Journal

Experimental biology and medicine (Maywood, N.J.)

Abbr.

Exp Biol Med (Maywood)

ISSN

1535-3702

DOI

10.1177/153537020623100713

[email protected]

Published

2006-07-00

Pages

1271-81

Language

English

Region

England

NLM ID

100973463

Subset

Grants

PHS HHS · C099996 · United States

NCI NIH HHS · CA104213 · United States

NCI NIH HHS · CA106471 · United States

NCI NIH HHS · CA93404 · United States

NIEHS NIH HHS · ES014621 · United States

External Links

PubMed source DOI: 10.1177/153537020623100713 View journal details

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Retinoblastoma tumor suppressor: where cancer meets the cell cycle.

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