-
SSeCKS/Gravin/AKAP12 metastasis suppressor inhibits podosome formation via RhoA- and Cdc42-dependent pathways.
Mol Cancer Res. 2006 Mar;4(3):151-8
PMID: 16547152
-
Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment.
Cell Mol Life Sci. 2006 Feb;63(4):449-68
PMID: 16416030
-
Mitogen-activated protein kinase kinase 4/stress-activated protein/Erk kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17.
Cancer Res. 1999 Nov 1;59(21):5483-7
PMID: 10554023
-
Gelsolin deficiency blocks podosome assembly and produces increased bone mass and strength.
J Cell Biol. 2000 Feb 21;148(4):665-78
PMID: 10684249
-
Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the raf kinase inhibitor protein.
Mol Cell Biol. 2000 May;20(9):3079-85
PMID: 10757792
-
Connective tissue growth factor: what's in a name?
Mol Genet Metab. 2000 Sep-Oct;71(1-2):276-92
PMID: 11001822
-
Radical cystectomy in the treatment of invasive bladder cancer: long-term results in 1,054 patients.
J Clin Oncol. 2001 Feb 1;19(3):666-75
PMID: 11157016
-
Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation.
Physiol Rev. 2001 Apr;81(2):807-69
PMID: 11274345
-
Multifunctional strands in tight junctions.
Nat Rev Mol Cell Biol. 2001 Apr;2(4):285-93
PMID: 11283726
-
Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions.
Endocr Rev. 2001 Apr;22(2):153-83
PMID: 11294822
-
KSR: a MAPK scaffold of the Ras pathway?
J Cell Sci. 2001 May;114(Pt 9):1609-12
PMID: 11309192
-
N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells.
Cancer Res. 2001 May 1;61(9):3819-25
PMID: 11325858
-
The Src-suppressed C kinase substrate, SSeCKS, is a potential metastasis inhibitor in prostate cancer.
Cancer Res. 2001 Jul 15;61(14):5644-51
PMID: 11454719
-
Gelsolin functions as a metastasis suppressor in B16-BL6 mouse melanoma cells and requirement of the carboxyl-terminus for its effect.
Int J Cancer. 2001 Sep15;93(6):773-80
PMID: 11519036
-
Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins.
J Cell Biol. 2001 Oct 29;155(3):459-70
PMID: 11684710
-
Role of endothelin-1 in lung disease.
Respir Res. 2001;2(2):90-101
PMID: 11686871
-
Suppression of human melanoma metastasis by the metastasis suppressor gene, BRMS1.
Exp Cell Res. 2002 Feb 15;273(2):229-39
PMID: 11822878
-
MMTV-associated transcription factor binding sites increase nm23-H1 metastasis suppressor gene expression in human breast carcinoma cell lines.
Clin Exp Metastasis. 2002;19(1):35-42
PMID: 11918081
-
Tetraspanin KAI1/CD82 suppresses invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases.
Oncogene. 2006 Apr 13;25(16):2367-78
PMID: 16331263
-
Suppression of human ovarian carcinoma metastasis by the metastasis-suppressor gene, BRMS1.
Int J Gynecol Cancer. 2006 Mar-Apr;16(2):522-31
PMID: 16681721
-
KAI1/CD82, a tumor metastasis suppressor.
Cancer Lett. 2006 Aug 28;240(2):183-94
PMID: 16260083
-
Metastasis suppression: the evolving role of metastasis suppressor genes for regulating cancer cell growth at the secondary site.
J Urol. 2003 Mar;169(3):1122-33
PMID: 12576866
-
Neutrophils with a license to kill: permeabilized, not stirred.
Dev Cell. 2003 Feb;4(2):146-8
PMID: 12586056
-
Effect of endothelin-A receptor blockade with atrasentan on tumor progression in men with hormone-refractory prostate cancer: a randomized, phase II, placebo-controlled trial.
J Clin Oncol. 2003 Feb 15;21(4):679-89
PMID: 12586806
-
Metastasis suppressor genes: basic biology and potential clinical use.
Clin Breast Cancer. 2003 Apr;4(1):51-62
PMID: 12744759
-
RECK: a novel suppressor of malignancy linking oncogenic signaling to extracellular matrix remodeling.
Cancer Metastasis Rev. 2003 Jun-Sep;22(2-3):167-75
PMID: 12784995
-
Histone deacetylase inhibitor up-regulates RECK to inhibit MMP-2 activation and cancer cell invasion.
Cancer Res. 2003 Jun 15;63(12):3069-72
PMID: 12810630
-
Effects of raf kinase inhibitor protein expression on suppression of prostate cancer metastasis.
J Natl Cancer Inst. 2003 Jun 18;95(12):878-89
PMID: 12813171
-
Deficiency of kinase suppressor of Ras1 prevents oncogenic ras signaling in mice.
Cancer Res. 2003 Jul 15;63(14):4232-8
PMID: 12874031
-
Metastasis suppressor pathways--an evolving paradigm.
Cancer Lett. 2003 Jul 30;198(1):1-20
PMID: 12893425
-
Endothelin-1 induces vascular endothelial growth factor by increasing hypoxia-inducible factor-1alpha in ovarian carcinoma cells.
J Biol Chem. 2002 Aug 2;277(31):27850-5
PMID: 12023962
-
Dissemination and growth of cancer cells in metastatic sites.
Nat Rev Cancer. 2002 Aug;2(8):563-72
PMID: 12154349
-
A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor.
Cancer Cell. 2002 Oct;2(4):301-14
PMID: 12398894
-
RhoGDI2 is an invasion and metastasis suppressor gene in human cancer.
Cancer Res. 2002 Nov 15;62(22):6418-23
PMID: 12438227
-
An alternatively spliced cadherin-11 enhances human breast cancer cell invasion.
Cancer Res. 2002 Nov 15;62(22):6688-97
PMID: 12438268
-
Mitogen-activated protein kinase kinase 4 (MKK4) acts as a metastasis suppressor gene in human ovarian carcinoma.
Cancer Res. 2002 Nov 15;62(22):6717-23
PMID: 12438272
-
Cellular adhesion pathways and metastatic potential of human melanoma.
Cancer Biol Ther. 2002 Sep-Oct;1(5):459-65
PMID: 12496470
-
Metastasis suppressors alter the signal transduction of cancer cells.
Nat Rev Cancer. 2003 Jan;3(1):55-63
PMID: 12509767
-
Melanoma metastasis suppression by chromosome 6: evidence for a pathway regulated by CRSP3 and TXNIP.
Cancer Res. 2003 Jan 15;63(2):432-40
PMID: 12543799
-
The endothelin axis: emerging role in cancer.
Nat Rev Cancer. 2003 Feb;3(2):110-6
PMID: 12563310
-
Overexpression of cadherins suppresses pulmonary metastasis of osteosarcoma in vivo.
Int J Cancer. 2003 Mar 20;104(2):147-54
PMID: 12569568
-
Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2-terminal kinase kinases JNKK1/MKK4 and MKK7.
Cancer Res. 2005 Dec 1;65(23):10984-91
PMID: 16322247
-
Exploiting the PI3K/AKT pathway for cancer drug discovery.
Nat Rev Drug Discov. 2005 Dec;4(12):988-1004
PMID: 16341064
-
Phase I dose-escalation study of the safety and pharmacokinetics of atrasentan: an endothelin receptor antagonist for refractory prostate cancer.
Clin Cancer Res. 2003 Aug 1;9(8):2965-72
PMID: 12912943
-
Dexamethasone and medroxyprogesterone acetate elevate Nm23-H1 metastasis suppressor gene expression in metastatic human breast carcinoma cells: new uses for old compounds.
Clin Cancer Res. 2003 Sep 1;9(10 Pt 1):3763-72
PMID: 14506169
-
Claudin-4 expression decreases invasiveness and metastatic potential of pancreatic cancer.
Cancer Res. 2003 Oct 1;63(19):6265-71
PMID: 14559813
-
Medicine. Gene therapy--new challenges ahead.
Science. 2003 Oct 17;302(5644):400-1
PMID: 14563994
-
Connective tissue growth factor and its role in lung adenocarcinoma invasion and metastasis.
J Natl Cancer Inst. 2004 Mar 3;96(5):364-75
PMID: 14996858
-
Rho-regulatory proteins in breast cancer cell motility and invasion.
Breast Cancer Res Treat. 2004 Mar;84(1):49-60
PMID: 14999154
-
The basic biology of metastasis.
Cancer Treat Res. 2004;118:1-21
PMID: 15043186
-
Historical review: Endothelin.
Trends Pharmacol Sci. 2004 Apr;25(4):219-24
PMID: 15063086
-
Reduced expression of metastasis suppressor RhoGDI2 is associated with decreased survival for patients with bladder cancer.
Clin Cancer Res. 2004 Jun 1;10(11):3800-6
PMID: 15173088
-
Subcellular localization of A and B Nm23/NDPK subunits.
Exp Cell Res. 2004 Aug 1;298(1):275-84
PMID: 15242782
-
High-dose oral medroxyprogesterone acetate or tamoxifen as adjuvant hormone therapy for node-negative early-stage breast cancer: randomized trial with 7-year update.
Clin Breast Cancer. 2004 Jun;5(2):136-41
PMID: 15245618
-
The biology and clinical relevance of the PTEN tumor suppressor pathway.
J Clin Oncol. 2004 Jul 15;22(14):2954-63
PMID: 15254063
-
Long-term survival of a patient with primarily chemo-resistant metastatic breast cancer treated with medroxyprogesterone acetate.
Breast. 2004 Aug;13(4):321-4
PMID: 15325667
-
Oxidative stress and thioredoxin-interacting protein promote intravasation of melanoma cells.
Exp Cell Res. 2004 Nov 1;300(2):297-307
PMID: 15474995
-
Control of cytoplasmic actin gel-sol transformation by gelsolin, a calcium-dependent regulatory protein.
Nature. 1979 Oct 18;281(5732):583-6
PMID: 492320
-
Cell-adhesion molecule uvomorulin is localized in the intermediate junctions of adult intestinal epithelial cells.
J Cell Biol. 1985 Jan;100(1):327-32
PMID: 3880756
-
Evidence for a novel gene associated with low tumor metastatic potential.
J Natl Cancer Inst. 1988 Apr 6;80(3):200-4
PMID: 3346912
-
Altered expression of NM23, a gene associated with low tumor metastatic potential, during adenovirus 2 Ela inhibition of experimental metastasis.
Cancer Res. 1988 Nov 15;48(22):6550-4
PMID: 2460224
-
Tissue and subcellular distributions of an inhibitory GDP/GTP exchange protein (GDI) for the rho proteins by use of its specific antibody.
Biochem Biophys Res Commun. 1991 Feb 28;175(1):199-206
PMID: 1900152
-
Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm23-transfected melanoma cells.
Cell. 1991 Apr 5;65(1):25-35
PMID: 2013093
-
Tumor metastasis and nm23: current concepts.
Cancer Cells. 1991 Jul;3(7):257-62
PMID: 1911039
-
Localization of CD44 (P80) on the external surface of a human astrocytoma cell.
Neuroreport. 1991 Aug;2(8):441-4
PMID: 1912477
-
The stress-activated protein kinase subfamily of c-Jun kinases.
Nature. 1994 May 12;369(6476):156-60
PMID: 8177321
-
KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2.
Science. 1995 May 12;268(5212):884-6
PMID: 7754374
-
CD44 isoforms in metastatic cancer.
Invasion Metastasis. 1994-1995;14(1-6):82-6
PMID: 7544777
-
The role of CD44 splice variants in human metastatic cancer.
Ciba Found Symp. 1995;189:142-51; discussion 151-6, 174-6
PMID: 7587629
-
Expression of CD44 splice variants in metastatic and non-metastatic mouse tumour cell lines.
Immunol Lett. 1996 Sep;52(2-3):81-7
PMID: 8905400
-
CD44 is a metastasis suppressor gene for prostatic cancer located on human chromosome 11p13.
Cancer Res. 1997 Mar 1;57(5):846-9
PMID: 9041184
-
The effects of n-6 polyunsaturated fatty acids on the expression of nm-23 in human cancer cells.
Br J Cancer. 1998 Mar;77(5):731-8
PMID: 9514051
-
Metastasis suppression by the standard CD44 isoform does not require the binding of prostate cancer cells to hyaluronate.
Cancer Res. 1998 Jun 1;58(11):2350-2
PMID: 9622073
-
Hypoxia and endothelin-1 induce VEGF production in human vascular smooth muscle cells.
Life Sci. 1998;63(6):477-84
PMID: 9718071
-
An essential part for Rho-associated kinase in the transcellular invasion of tumor cells.
Nat Med. 1999 Feb;5(2):221-5
PMID: 9930872
-
Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP.
Nature. 1999 Sep 9;401(6749):173-7
PMID: 10490027
-
PTEN up-regulates the tumor metastasis suppressor gene Drg-1 in prostate and breast cancer.
Cancer Res. 2004 Nov 1;64(21):7655-60
PMID: 15520163
-
Microarrays bring new insights into understanding of breast cancer metastasis to bone.
Breast Cancer Res. 2004;6(2):61-4
PMID: 14979907
-
Unoccupied alpha(v)beta3 integrin regulates osteoclast apoptosis by transmitting a positive death signal.
Mol Endocrinol. 2005 Mar;19(3):771-80
PMID: 15591537
-
Medroxyprogesterone acetate elevation of Nm23-H1 metastasis suppressor expression in hormone receptor-negative breast cancer.
J Natl Cancer Inst. 2005 May 4;97(9):632-42
PMID: 15870434
-
Challenges in Advancing the Field of Gene Therapy--American Society of Gene Therapy Stakeholders' Meeting. A critical review of the science, medicine and regulation.
IDrugs. 2005 Jun;8(6):483-6
PMID: 15906194
-
GDIs: central regulatory molecules in Rho GTPase activation.
Trends Cell Biol. 2005 Jul;15(7):356-63
PMID: 15921909
-
Endothelin axis is a target of the lung metastasis suppressor gene RhoGDI2.
Cancer Res. 2005 Aug 15;65(16):7320-7
PMID: 16103083
-
Transendothelial migration of melanoma cells involves N-cadherin-mediated adhesion and activation of the beta-catenin signaling pathway.
Mol Biol Cell. 2005 Sep;16(9):4386-97
PMID: 15987741
-
RhoC is dispensable for embryogenesis and tumor initiation but essential for metastasis.
Genes Dev. 2005 Sep 1;19(17):1974-9
PMID: 16107613
-
The KISS1 metastasis suppressor: mechanistic insights and clinical utility.
Front Biosci. 2006;11:647-59
PMID: 16146758
-
Transforming growth factor-beta regulation of epithelial tight junction proteins enhances barrier function and blocks enterohemorrhagic Escherichia coli O157:H7-induced increased permeability.
Am J Pathol. 2005 Dec;167(6):1587-97
PMID: 16314472
-
Anoikis and survival connections in the tumor microenvironment: is there a role in prostate cancer metastasis?
Cancer Res. 2005 Dec 15;65(24):11230-5
PMID: 16357123
-
Translational molecular imaging for cancer.
Cancer Imaging. 2005;5 Spec No A:S16-26
PMID: 16361132
-
Potentiation of neuroblastoma metastasis by loss of caspase-8.
Nature. 2006 Jan 5;439(7072):95-9
PMID: 16397500
-
Macrophages: obligate partners for tumor cell migration, invasion, and metastasis.
Cell. 2006 Jan 27;124(2):263-6
PMID: 16439202
-
Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays.
J Clin Oncol. 2006 Feb 10;24(5):778-89
PMID: 16432078
-
Inhibition of ovarian cancer metastasis by adeno-associated virus-mediated gene transfer of nm23H1 in an orthotopic implantation model.
Cancer Gene Ther. 2006 Mar;13(3):266-72
PMID: 16179930
-
The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma.
Cancer Res. 2006 Feb 15;66(4):2264-70
PMID: 16489030